N-Cbz-PTE: A Versatile Phosphonoglycine Derivative for Advanced Chemical Synthesis
Discover the critical role of N-Cbz-PTE in peptide research and organic synthesis.
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(±)-Cbz-a-phosphonoglycine trimethyl ester
N-Cbz-PTE is a vital organic compound that acts as a key starting material in sophisticated chemical synthesis. Its primary utility lies in its role in the Wittig-Horner reaction with aldehydes to produce (Z)-dehydroamino acids, which are subsequently stereoselectively reduced into amino acids. This makes it an indispensable tool in amino acid and peptide research.
- Explore the synthesis of (Z)-dehydroamino acids using the Wittig-Horner reaction with aldehydes, a primary application of N-Cbz-PTE.
- Understand how N-Cbz-PTE is crucial for the stereoselective reduction of dehydroamino acids into valuable amino acid derivatives.
- Learn about the use of N-Cbz-PTE in the synthesis of calcitonin gene-related peptide antagonists, showcasing its pharmaceutical relevance.
- Discover the utility of this phosphonoglycine derivative as a critical intermediate for amino acid and peptide research.
Key Advantages
Versatile Synthetic Intermediate
Leverage N-Cbz-PTE as a versatile building block in organic synthesis, facilitating the creation of complex molecules through established reaction pathways like the Wittig-Horner reaction.
Enhances Peptide Research
This phosphonoglycine derivative significantly contributes to amino acid and peptide research by enabling the synthesis of specific dehydroamino acid esters crucial for understanding peptide structures and functions.
Pharmaceutical Relevance
The compound's application in synthesizing calcitonin gene-related peptide antagonists highlights its importance in the pharmaceutical sector for drug development and therapeutic research.
Key Applications
Organic Synthesis
N-Cbz-PTE is a cornerstone for various organic synthesis pathways, particularly those involving the formation of carbon-phosphorus bonds and amino acid modifications.
Peptide Synthesis
Its role in creating dehydroamino acids makes it invaluable for advanced peptide synthesis, enabling the construction of novel peptide sequences for research and development.
Pharmaceutical Development
Used in the synthesis of potential drug candidates like calcitonin gene-related peptide antagonists, this chemical intermediate supports pharmaceutical discovery.
Biochemical Research
Researchers utilize N-Cbz-PTE for a broad range of biochemical investigations, particularly those focusing on amino acids, peptides, and their biological activities.