Propargyl-PEG5-NHS Ester: Advanced Click Chemistry Reagent for Bioconjugation and Drug Delivery
Harness the power of click chemistry and amine reactivity with our advanced PEGylated linker.
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Propargyl-PEG5-NHS Ester
Propargyl-PEG5-NHS ester is a highly versatile bifunctional linker designed for sophisticated bioconjugation and material modification applications. It uniquely combines an amine-reactive NHS ester with a clickable propargyl group, bridged by a hydrophilic polyethylene glycol (PEG) chain. This design facilitates targeted modification of biomolecules and surfaces, enabling advancements in drug delivery, diagnostics, and nanotechnology.
- Amine-reactive NHS ester allows for efficient derivatization of peptides, antibodies, and amine-coated surfaces, forming stable amide bonds.
- The terminal propargyl group is a key component for robust click chemistry reactions, particularly with azide-containing molecules, forming a stable triazole linkage.
- The hydrophilic PEG spacer significantly enhances the water solubility of the conjugate, improving its biocompatibility and performance in aqueous environments.
- Utilize this reagent for sophisticated applications such as Antibody-Drug Conjugates (ADCs), PROTACs, and surface functionalization for biosensors.
Advantages You'll Gain
Enhanced Biocompatibility
The incorporation of the hydrophilic PEG spacer in Propargyl-PEG5-NHS ester improves the solubility and reduces the immunogenicity of conjugates, a crucial aspect when developing bioconjugation strategies for therapeutic applications.
Dual Functionality for Precision Conjugation
With both amine reactivity and click chemistry capabilities, this linker provides researchers with dual points of attachment for precise molecular construction, essential for creating complex bioconjugates.
Streamlined Synthesis Pathways
The well-defined reactive groups and the hydrophilic nature of the PEG chain simplify conjugation protocols, potentially reducing the complexity of synthesis and purification steps in your research.
Key Applications
Bioconjugation
Employ Propargyl-PEG5-NHS ester for selective modification of proteins, peptides, and antibodies, essential for creating targeted therapeutics and diagnostic agents.
Drug Delivery Systems
Leverage this linker to develop advanced drug delivery vehicles, improving drug solubility and targeting efficiency, crucial for effective therapeutic outcomes.
Surface Modification
Functionalize surfaces of nanoparticles, microarrays, or other materials to introduce specific properties for biosensing, diagnostics, or biocompatible coatings.
PROTACs and ADCs Development
Integral component in the synthesis of targeted protein degraders (PROTACs) and Antibody-Drug Conjugates (ADCs), enabling precise attachment of payloads.