TosMIC: A Versatile Reagent for Heterocyclic Synthesis and Ketone Conversion
Unlock complex molecular structures with this essential reagent for organic synthesis and medicinal chemistry.
Get a Quote & SampleProduct Core Value
Tosylmethyl isocyanide
Tosylmethyl isocyanide (TosMIC) stands out as a highly versatile synthon in organic chemistry. It is instrumental in facilitating the Van Leusen reaction, a process that effectively converts ketones into nitriles with an additional carbon atom in a single pot. Beyond this, TosMIC is a crucial building block for the synthesis of a wide array of biologically active heterocyclic compounds, including imidazoles, pyrroles, and oxazoles, making it indispensable in medicinal chemistry research and development.
- Discover the ease of ketone to nitrile conversion using TosMIC, a key aspect of nitrile synthesis explored in various organic chemistry applications.
- Explore the broad utility of TosMIC in medicinal chemistry, particularly in creating novel HIV-1 attachment inhibitors by facilitating the synthesis of complex azaindole cores.
- Learn about the efficient preparation of biologically active pyrroles, a significant contribution of TosMIC to heterocyclic chemistry.
- Understand why sourcing Tosylmethyl isocyanide from reliable suppliers is critical for consistent results in your advanced organic synthesis projects.
Key Advantages
Reaction Versatility
TosMIC offers unparalleled versatility, serving as a C-N=C synthon for diverse heterocyclic formations and a reagent for ketone to nitrile conversion, significantly aiding nitrile synthesis.
Medicinal Chemistry Impact
Its application in medicinal chemistry is profound, enabling the synthesis of pharmacologically active compounds, such as potent HIV-1 attachment inhibitors, underscoring its role in advancing healthcare.
Ease of Use & Stability
As a stable, colorless, and odorless solid, TosMIC is convenient to handle and store at room temperature, differentiating it from many other isocyanides and simplifying its integration into laboratory workflows.
Key Applications
Heterocyclic Synthesis
Utilize TosMIC for the straightforward synthesis of various azoles, including pyrroles, oxazoles, and imidazoles, fundamental structures in organic and medicinal chemistry.
Nitrile Preparation
Leverage TosMIC in the Van Leusen reaction for an efficient method to convert ketones into nitriles, a vital transformation for organic synthesis.
Medicinal Chemistry Research
Employ TosMIC as a key building block in drug discovery, particularly in synthesizing novel therapeutic agents like HIV-1 attachment inhibitors.
Organic Synthesis Tool
Incorporate TosMIC into your synthetic strategies for introducing one-carbon units and creating complex molecular architectures, supporting precise organic chemistry endeavors.
Related Technical Articles & Resources
Why Choose Us?
Leverage our expertise and state-of-the-art infrastructure to accelerate your journey from discovery to commercial success.
Global Experience
With 20 years of R&D, manufacturing, and sales experience, we proudly serve clients across 60 countries and regions worldwide.
Advanced Facilities
Our in-house R&D laboratory, pilot platform, and large-scale production workshop are equipped to meet the audit requirements of global customers.
Seamless Scalability
We facilitate a perfect transition from small-scale lab requirements (grams) to full commercialization (hundreds of tons).