Tributyltin Azide CAS 17846-68-3: Synthesis, Applications, and Safety in Organic Chemistry

Explore the versatile applications and critical safety considerations of Tributyltin Azide, a key organotin compound essential for modern organic synthesis and pharmaceutical development.

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Versatile Reactivity

Tributyltin Azide (CAS 17846-68-3) showcases remarkable reactivity, facilitating key organic synthesis transformations like [3+2] cycloadditions with nitriles to form 5-substituted 1H-tetrazoles, a cornerstone for producing essential pharmaceutical intermediates.

Pharmaceutical Applications

This chemical reagent plays a critical role in the synthesis of blockbuster drugs, particularly angiotensin II receptor antagonists, highlighting its significance in pharmaceutical intermediate manufacturing and the development of life-saving medications.

Energetic Material Precursor

The compound is instrumental in developing nitrogen-rich energetic materials, leveraging the high nitrogen content of tetrazole derivatives for applications in propellants and explosives, pushing the boundaries of material science.

Key Applications

Organic Synthesis

Tributyltin Azide serves as a crucial chemical reagent in various organic synthesis pathways, most notably for the efficient formation of tetrazole rings, which are vital building blocks in medicinal chemistry.

Pharmaceutical Intermediates

Its application as a pharmaceutical intermediate is paramount in the production of widely prescribed drugs such as sartans (e.g., Losartan, Valsartan), underscoring its importance in the healthcare sector.

Materials Science

The unique properties of Tributyltin Azide make it a subject of interest in materials science for the development of novel functional materials and advanced chemical applications.

Energetic Materials Development

Research utilizes this organotin compound to synthesize nitrogen-rich energetic materials, contributing to advancements in high-performance explosives and propellants.