Trimethylsulfoxonium Chloride: A Versatile Reagent in Organic Synthesis and Chemical Applications
Unlock precise chemical transformations with this key sulfur ylide precursor, essential for modern synthetic chemistry.
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Trimethylsulfoxonium Chloride
Trimethylsulfoxonium Chloride is a crucial reagent in organic synthesis, known for its ability to generate dimethylsulfoxonium methylide. This ylide is instrumental in the Corey-Chaykovsky reaction, facilitating the formation of epoxides and cyclopropanes from carbonyl compounds and enones, respectively. Its high purity and stability make it an indispensable tool for complex molecule construction and advanced chemical transformations.
- A versatile methylating agent: Facilitates the introduction of methyl groups in various organic compounds, crucial for synthesizing ethers and quaternary ammonium salts.
- Precursor to sulfonium ylides: Essential for generating dimethylsulfoxonium methylide, a key intermediate in the Corey-Chaykovsky reaction.
- Epoxidation and cyclopropanation: Enables the stereoselective synthesis of epoxides and cyclopropanes, vital for building complex molecular architectures.
- High purity and stability: With purity ≥98.0%, it ensures reliable and reproducible results in demanding synthetic procedures.
Key Advantages
Controlled Reactivity
The controlled reactivity of Trimethylsulfoxonium Chloride allows for selective transformations, minimizing side reactions and maximizing yield in organic synthesis.
Synthetic Versatility
Its role as a methylating agent and ylide precursor makes it highly versatile, applicable across a wide range of chemical applications.
Complex Molecule Synthesis
Crucial for constructing complex molecules, its application in total syntheses highlights its importance in advanced organic synthesis methodologies.
Key Applications
Organic Synthesis
Serves as a key reagent for carbon-carbon bond formation and functional group interconversion in the synthesis of fine chemicals.
Epoxidation Reactions
A primary precursor for generating sulfur ylides used in the Corey-Chaykovsky reaction to form epoxides.
Cyclopropanation
Enables the synthesis of cyclopropane rings, a common motif in pharmaceuticals and natural products.
Methylation
Acts as an effective methylating agent for various nucleophiles, including alcohols and amines.