Unlock Efficient Peptide Synthesis: Understanding Fmoc-Rink Amide MBHA Resin
Discover the key advantages of Rink Amide MBHA resin for your peptide synthesis needs.
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Fmoc-Rink Amide MBHA Resin
Fmoc-Rink Amide MBHA resin is a crucial component in solid-phase peptide synthesis (SPPS), particularly favored for its efficiency in producing C-terminal amide peptides. Its unique structure, featuring a benzhydrylamine linker attached via an electron-withdrawing acetamido spacer, makes it less susceptible to acid degradation compared to standard Rink Amide resin. This characteristic is vital for researchers aiming to achieve high yields and purity in complex peptide syntheses. The resin is compatible with the widely used Fmoc protecting group strategy, allowing for controlled coupling of amino acids under mild conditions and subsequent cleavage using trifluoroacetic acid (TFA).
- Leveraging Rink Amide MBHA resin for SPPS offers enhanced stability and reduced acid lability, critical for synthesizing challenging peptide sequences.
- Researchers widely utilize this resin for drug development, where precise peptide structures are essential for therapeutic efficacy.
- The resin's ability to facilitate high-throughput screening makes it invaluable for identifying novel peptide-based drug candidates efficiently.
- Understanding the optimal cleavage conditions, typically involving TFA treatment, ensures maximum yield and purity of synthesized peptides.
Key Advantages
Reduced Acid Sensitivity
The acetamido spacer in the benzhydrylamine linker provides superior resistance to acid compared to standard Rink Amide resin, safeguarding peptide integrity during synthesis and cleavage.
Versatile Fmoc Compatibility
Easily integrates with the Fmoc protecting group strategy, a cornerstone of modern solid phase peptide synthesis, allowing for controlled amino acid coupling.
Enhanced Peptide Purity and Yield
The resin's properties contribute to higher yields and improved purity of synthesized peptides, crucial for reliable research outcomes and pharmaceutical applications.
Key Applications
Peptide Synthesis
Serves as a foundational support for creating peptide chains via solid-phase methods, enabling the efficient production of custom peptides for various research purposes.
Drug Development
A critical tool in creating peptide-based therapeutics, aiding in the development of new drugs to treat a wide range of diseases.
Bioconjugation
Facilitates the attachment of peptides to other molecules, enhancing the functionality of diagnostics and targeted therapies in the biomedical field.
High-Throughput Screening
Supports the rapid synthesis of diverse peptide libraries, accelerating the discovery process for new compounds with potential medicinal properties.
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