High Purity Hypromellose Acetate Succinate (HPMCAS) for Pharmaceutical Enteric Coating and Solid Dispersion
Unlock superior drug delivery with our high-quality Hypromellose Acetate Succinate (HPMCAS).
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Hypromellose Acetate Succinate
Hypromellose Acetate Succinate (HPMCAS) is a versatile and high-performance pharmaceutical excipient renowned for its critical roles in enteric coating and as a carrier for solid dispersions, significantly improving drug solubility and bioavailability. It offers excellent film-forming capabilities, negating the need for plasticizers, and exhibits favorable solubility in the duodenum, thereby enhancing drug absorption within the small intestine.
- Utilize HPMCAS as a leading polymer for solid dispersion technology to enhance drug solubility and bioavailability, a key aspect for poorly water-soluble APIs.
- Achieve effective enteric coating with excellent film-forming properties, offering good solubility in the upper small intestine for controlled drug release.
- Benefit from its versatility across both aqueous and solvent-based coating systems, providing flexibility in manufacturing processes.
- Ensure compliance with stringent pharmaceutical standards (USP/NF, JP, EP) for reliable and safe drug formulations.
Key Advantages
Enhanced Drug Solubility
Leverage HPMCAS's ability to improve the solubility of poorly water-soluble drugs, a critical step in boosting drug bioavailability enhancement.
Superior Enteric Coating
Employ HPMCAS for precise enteric coating, ensuring drugs are protected in the stomach and released in the small intestine, a core application of this pharmaceutical excipient HPMCAS.
Versatile Solid Dispersion Carrier
Utilize HPMCAS as a carrier for advanced techniques like Hot Melt Extrusion (HME) and spray drying, crucial for creating effective HPMCAS solid dispersion carrier formulations.
Key Applications
Enteric Coating
HPMCAS is extensively used for enteric coating of tablets, capsules, and pellets, protecting sensitive drugs from gastric acidity and ensuring targeted release in the intestine.
Solid Dispersion
As a leading polymer in solid dispersion technology, HPMCAS enhances the solubility of poorly soluble drugs when used in methods like spray drying and Hot Melt Extrusion (HME).
Controlled Release
Its pH-dependent dissolution properties allow for the development of sophisticated controlled and sustained-release drug formulations.
Taste Masking
HPMCAS can also contribute to taste masking by forming a barrier that prevents immediate interaction with taste receptors.