Synthesis and Applications of a Critical Pharmaceutical Intermediate: Compound 571188-82-4
Explore the chemical structure and significance of this vital building block in modern drug discovery.
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![4-[6-(6-Bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-y](https://www.nbinno.com/2025/webimg/gemini_688d5cab26437_1754094763.png)
4-[6-(6-Bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester
This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents, most notably Palbociclib, an investigational drug targeting specific kinases involved in cancer proliferation. Its complex heterocyclic structure, featuring bromine, a cyclopentyl ring, and a tert-butyl ester, makes it a valuable building block for targeted therapies.
- Understanding the Palbociclib intermediate synthesis is key for developing next-generation cancer treatments, leveraging compounds like this for precise molecular targeting.
- The presence of bromine and a complex pyrido[2,3-d]pyrimidine core in this CDK4 and CDK6 inhibitor precursor highlights its role in creating potent therapeutic agents.
- This tert-butyl ester derivative for drug development offers specific reactivity and protection for subsequent synthetic steps in creating active pharmaceutical ingredients.
- Exploring fine chemical custom synthesis for drug discovery is essential, and intermediates like this are vital for efficient and scalable production of novel pharmaceuticals.
Key Advantages
Precise Molecular Design
The intricate structure of this compound allows for precise manipulation in advanced organic synthesis, contributing to the development of highly specific drugs like Palbociclib.
Essential for Targeted Therapies
As a CDK4 and CDK6 inhibitor precursor, it plays a crucial role in creating treatments that target cell cycle progression in various cancers.
Facilitates Scalable Production
The compound's availability as a pharmaceutical intermediate aids in the efficient and scalable manufacturing processes required for drug development and commercialization.
Key Applications
Oncology Drug Synthesis
This compound is a vital building block in the synthesis of targeted cancer therapies, specifically those inhibiting CDK4 and CDK6, such as Palbociclib.
Pharmaceutical Intermediates
Serves as a high-quality intermediate for the creation of complex heterocyclic active pharmaceutical ingredients (APIs) and their related impurities.
Drug Discovery Research
Essential for researchers in drug discovery and development, enabling the exploration of new therapeutic compounds and their synthesis pathways.
Chemical Synthesis Building Block
Its unique structural features make it a valuable component in various custom synthesis projects for novel organic molecules.
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