Synthesis and Applications of 4-Chloro-3-nitro-5-sulfamoylbenzoic Acid
A vital pharmaceutical intermediate that plays a key role in the development of life-saving medications.
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4-Chloro-3-nitro-5-sulfamoylbenzoic acid
This chemical compound is indispensable in the pharmaceutical sector, serving as a critical building block for active pharmaceutical ingredients (APIs). Its unique chemical structure, featuring sulfonamide and nitro groups, makes it a valuable intermediate in the complex synthesis of drugs like Bumetanide, a potent diuretic. Beyond its primary application, this compound is also explored in the synthesis of novel molecules for potential therapeutic applications and plays a role in regulatory processes such as Abbreviated New Drug Application (ANDA) and Drug Master File (DMF) submissions.
- The chemical synthesis of Bumetanide relies heavily on this intermediate, highlighting its importance in producing essential medications for managing conditions like edema and hypertension.
- As a key intermediate in pharmaceutical R&D, understanding the properties of 4-Chloro-3-nitro-5-sulfamoylbenzoic acid is crucial for optimizing drug development processes.
- The compound's functional groups, including sulfonamide and nitro, allow for diverse chemical reactions, making it a versatile reagent in organic synthesis.
- Its utilization in analytical studies and quality control ensures the purity and efficacy of the final pharmaceutical products.
Key Advantages
Versatile Chemical Reactivity
The presence of multiple reactive functional groups, including the nitro and sulfonamide moieties, enables 4-Chloro-3-nitro-5-sulfamoylbenzoic acid to participate in a wide array of chemical transformations, facilitating complex organic synthesis.
Critical for Bumetanide Production
As a vital link in the Bumetanide synthesis pathway, this intermediate ensures the consistent and efficient production of a widely used diuretic medication, directly impacting public health.
Supports Regulatory Filings
The availability of comprehensive analytical data and its role in studies for ANDA and DMF filings make this compound a preferred choice for pharmaceutical companies navigating regulatory landscapes.
Key Applications
Pharmaceutical Synthesis
This compound is a cornerstone for the chemical synthesis of various pharmaceutical drugs, most notably Bumetanide, a critical diuretic.
Drug Development
It serves as a valuable building block in the exploration and development of novel therapeutic agents, allowing researchers to construct complex molecular structures.
Quality Control & Analytical Studies
Used in laboratory settings for analytical studies and quality control to ensure the purity and consistency of drug substances.
Regulatory Compliance
Its role in supporting Abbreviated New Drug Application (ANDA) and Drug Master File (DMF) submissions makes it indispensable for pharmaceutical manufacturers.