7-Dehydrocholesterol (CAS 434-16-2): A Key Vitamin D Precursor and Cholesterol Biosynthesis Intermediate
Explore the vital role of 7-dehydrocholesterol in Vitamin D synthesis and cholesterol pathways.
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7-Dehydrocholesterol
7-Dehydrocholesterol, with CAS number 434-16-2, is a critical provitamin that serves as the direct precursor to Vitamin D3. This conversion occurs in animal and human skin through the action of sunlight or ultraviolet irradiation. Furthermore, it is a fundamental intermediate in the cholesterol biosynthesis pathway, being converted to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the final step.
- Understanding the 7-dehydrocholesterol provitamin role is crucial for research into Vitamin D synthesis.
- The cholesterol biosynthesis intermediate function highlights its importance in fundamental biological processes.
- Investigating Smith-Lemli-Opitz syndrome 7-DHC links this compound to significant genetic disorders.
- The conversion pathway via UVB light vitamin D synthesis is key to understanding cutaneous Vitamin D production.
Advantages of 7-Dehydrocholesterol
Vitamin D Synthesis Pathway
As a 7-dehydrocholesterol provitamin, it's indispensable for the synthesis of Vitamin D3, vital for bone health and immune function, and understanding UVB light vitamin D synthesis is key.
Cholesterol Precursor Role
Its position as a direct precursor to cholesterol makes it central to studying cholesterol biosynthesis intermediate pathways and lipid metabolism.
Biomarker for Genetic Disorders
Elevated levels in conditions like Smith-Lemli-Opitz syndrome 7-DHC make it a significant indicator for research into these rare metabolic diseases.
Key Applications
Vitamin D Production
Essential for producing Vitamin D3 through exposure to UVB light, a critical process for human health.
Cholesterol Metabolism Research
Its role as a cholesterol biosynthesis intermediate is fundamental to understanding lipid regulation and metabolic pathways.
Smith-Lemli-Opitz Syndrome Studies
Investigating the link between Smith-Lemli-Opitz syndrome 7-DHC aids in understanding genetic defects in cholesterol synthesis.
Biochemical Research
Serves as a key compound for various biochemical studies involving steroid chemistry and cellular lipid pathways.