Boc-His(Trt)-OH: Your Key Building Block for Advanced Peptide Synthesis and Research
Unlock new possibilities in peptide synthesis with our high-quality Boc-His(Trt)-OH.
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Boc-His(Trt)-OH
Boc-His(Trt)-OH is a pivotal protected amino acid derivative essential for sophisticated peptide synthesis. Its meticulously designed structure, featuring N-alpha Boc protection and N-tau Trityl protection for the histidine imidazole side chain, along with the inclusion of alpha-aminoisobutyric acid (Aib), ensures precise control over reactions and enhances the stability and conformational properties of synthesized peptides. This makes it an indispensable tool for peptide drug development and cutting-edge biomedical research.
- Discover the advantages of using protected amino acids for SPPS, ensuring high purity and yield in your peptide synthesis projects.
- Explore the role of histidine imidazole protection in preventing side reactions and racemization during complex peptide chain elongation.
- Learn how Boc-His(Trt)-OH contributes to superior peptide stability and specific conformational profiles essential for targeted therapeutic applications.
- Leverage this vital building block for custom peptide synthesis, enabling the creation of novel peptides for drug discovery and research.
Key Advantages for Your Research
Suppressed Racemization
Utilize the Trityl group on histidine's imidazole side chain to significantly reduce racemization, ensuring the stereochemical integrity of your synthesized peptides and crucial for precise peptide drug development.
Enhanced Peptide Stability
The inclusion of Aib, an unnatural amino acid, promotes helical structures, thereby increasing peptide resistance to enzymatic degradation and extending its half-life, which is vital for peptide synthesis building blocks.
Seamless Boc Chemistry Integration
Benefit from the compatibility of Boc and Trt groups, which are cleaved under similar acidic conditions (TFA), simplifying deprotection steps and streamlining your solid phase peptide synthesis workflow.
Key Applications
Peptide Drug Development
Essential for creating peptides targeting diseases, where the stability and specific conformations enabled by Boc-His(Trt)-OH are crucial for effective therapeutics.
Biomedical Research
A valuable tool for studying peptide interactions, designing enzyme mimics, and exploring structure-activity relationships in various biological systems.
Custom Peptide Synthesis
Enables researchers to design and synthesize custom peptides with unique sequences and properties, supporting diverse research goals.
DNA-Encoded Libraries
Supports the rapid exploration of peptide chemical space for drug discovery by facilitating synthesis compatible with library generation techniques.