Brusatol: A Potent Nrf2 Inhibitor for Cancer Therapy Research
Explore the anticancer potential of Brusatol, a key Nrf2 pathway modulator.
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Brusatol
Brusatol, identified by CAS number 14907-98-3, is a plant-derived quassinoid renowned for its potent cytotoxic activity against a broad spectrum of cancer cell lines. Its primary mechanism involves the inhibition of de novo protein synthesis and the critical Nrf2 pathway, making it a promising candidate for cancer research and development.
- Understanding Brusatol's cytotoxic mechanism reveals its potential in sensitizing various cancer cells to chemotherapy.
- Research into the Nrf2 pathway inhibition by Brusatol sheds light on its therapeutic applications.
- The compound is being investigated for its role in conditions such as retinopathy, highlighting its diverse biological activities.
- As a pharmaceutical intermediate, Brusatol offers significant value in drug discovery and development pipelines.
Key Advantages of Brusatol
Potent Anticancer Activity
Brusatol demonstrates significant cytotoxicity, with IC50 values below 1 μM against numerous cancer cell lines, showcasing its efficacy in preclinical research.
Nrf2 Pathway Modulation
As a key inhibitor of the Nrf2 pathway, Brusatol offers a targeted approach for cancer treatment strategies, influencing cellular defense mechanisms.
Adjuvant Therapy Potential
The compound's ability to enhance chemotherapy efficacy positions it as a valuable agent for adjuvant cancer therapy.
Key Applications
Cancer Research
Investigating the Brusatol cytotoxicity mechanism in various cancer models provides crucial insights into its therapeutic potential.
Drug Discovery
As a novel Nrf2 inhibitor, Brusatol serves as a valuable tool in the development of new anticancer agents.
Ophthalmology Research
Studies exploring Brusatol retinopathy of prematurity research indicate its potential in treating certain ocular conditions.
Biochemical Assays
Brusatol is utilized in assays to understand the intricate workings of the Nrf2 pathway and its role in cellular processes.