Darusentan: A Selective Endothelin Receptor A Antagonist for Cardiovascular and Hypertension Research
Explore the potent ET-A receptor antagonist, Darusentan, crucial for understanding hypertension and cardiovascular disease mechanisms. A key molecule for pharmaceutical research and development.
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Darusentan
As a leading supplier in China, we provide high-purity Darusentan (CAS 171714-84-4), a critical research chemical for investigating Endothelin Receptor A antagonism. This compound plays a vital role in understanding and developing treatments for conditions like hypertension and cardiovascular diseases, making it an essential component in advanced pharmaceutical research.
- Explore the detailed mechanism of action for Darusentan as a selective ET-A receptor antagonist, understanding its impact on vasoconstriction.
- Investigate the cardiovascular drug development potential of Darusentan through in vitro and in vivo studies.
- Learn about Darusentan's role in hypertension treatment mechanisms and its application in preclinical research.
- Discover how Darusentan contributes to understanding myocardial perfusion, a key aspect of cardiovascular health.
Advantages Provided by the Product
High Selectivity for ET-A Receptors
Darusentan exhibits over 100-fold selectivity for ET-A receptors over ET-B receptors, enabling precise research into ET-A mediated pathways, which is crucial for accurate findings in hypertension treatment research.
Established Role in Cardiovascular Research
The compound is widely used in studies investigating cardiovascular disease mechanisms, making it a valuable tool for understanding conditions like hypertension and developing novel therapies.
Orally Bioavailable and Active In Vivo
Darusentan's oral bioavailability and in vivo activity, as demonstrated in various preclinical models, underscore its potential as a therapeutic agent and facilitate in-depth pharmacological studies.
Key Applications
Hypertension Research
Darusentan is pivotal in studying the mechanisms of hypertension by antagonizing ET-A receptors, contributing to the development of new antihypertensive drugs.
Cardiovascular Disease Studies
Its role in blocking endothelin-induced vasoconstriction makes it valuable for research into various cardiovascular conditions and their management.
Liver Transplantation Research
Studies have shown Darusentan's potential to improve liver repopulation after cell transplantation by mitigating hepatic ischemia and improving microcirculation.
Pharmacological Investigations
As a well-characterized compound, Darusentan serves as a standard for exploring endothelin signaling pathways and their effects on physiological processes.