DOTA-tris-tBu Ester NHS: Precision Bifunctional Chelator for Advanced Applications
Unlock innovative radiopharmaceuticals and bioconjugates with our high-purity DOTA-tris-tBu Ester NHS.
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DOTA-tris-tBu Ester NHS
Our DOTA-tris-tBu Ester NHS is a cutting-edge bifunctional chelator, meticulously engineered to bridge metal ions with biomolecules. Its robust DOTA macrocycle forms exceptionally stable complexes with various metal ions, crucial for preventing premature dissociation of radionuclides in vivo. The strategic tert-butyl ester protection on three carboxyl groups allows for precise, selective conjugation at the single unprotected carboxylic acid, ensuring high purity and specific attachment in complex synthetic pathways.
- Advanced radiopharmaceutical development: Facilitating the stable attachment of radiolabelled metal ions for advanced diagnostic imaging techniques such as PET and SPECT, aiding in targeted cancer therapy development.
- Versatile bioconjugation chemistry tools: Enabling the creation of sophisticated targeted delivery systems by covalently linking the chelator to peptides, antibodies, and other biomolecules, supporting molecular imaging reagents.
- Key intermediate for advanced radioconjugates: Serving as a foundational molecule for synthesizing more intricate DOTA derivatives with tailored functionalities for precise drug delivery.
- Exceptional stability and controlled reactivity: The DOTA core ensures high thermodynamic stability and kinetic inertness, while the protected groups offer meticulous control over reactivity during synthesis, making it a valuable pharmaceutical intermediate for imaging.
Key Advantages of Our Chelator
Unrivaled Metal Chelation
Experience superior binding affinity for a wide range of metal ions, crucial for minimizing non-target organ accumulation and enhancing targeted delivery.
Precision Bioconjugation
Achieve highly specific bioconjugates through selective reactivity at the unprotected site, simplifying complex synthetic routes and improving overall product quality.
Theranostic Potential
Facilitate a theranostic approach by enabling the simultaneous binding of diagnostic and therapeutic radioisotopes within the same chemical framework.
Key Applications
Radiopharmaceutical Synthesis
Enables precise labeling of diagnostic and therapeutic agents for advanced medical imaging and treatment strategies.
Bioconjugation
Acts as a critical linker for attaching metal complexes to biomolecules, creating targeted imaging probes and delivery systems.
Molecular Imaging
Essential for developing probes used in PET, SPECT, and MRI for accurate disease detection and monitoring.
Targeted Drug Delivery
Facilitates the selective delivery of radionuclides to specific cells or tissues, minimizing off-target effects and maximizing therapeutic outcomes.