Edoxaban Tosylate Hydrate Intermediate: Synthesis and Pharmaceutical Applications
Discover the efficient synthesis of a crucial pharmaceutical intermediate for anticoagulant therapies.
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Edoxaban Tosylate Hydrate Intermediate / Ethyl 2-((5-Chloropyridin-2-yl)Amino)-2-Oxoacetate Hydrochloride
This document details the synthesis of a key intermediate for Edoxaban Tosylate Hydrate, a widely used anticoagulant. It outlines a multi-step process involving ammonolysis, reduction, condensation, and salt formation. The article emphasizes the efficiency, mild reaction conditions, and industrial scalability of the described method, highlighting its suitability for producing high-yield and chiral-purity products. It also touches upon the therapeutic applications of Edoxaban, such as the treatment of deep vein thrombosis and pulmonary embolism.
- Explore the detailed edoxaban tosylate hydrate synthesis process, ensuring high purity for critical applications.
- Understand the preparation of Ethyl 2-((5-Chloropyridin-2-yl)Amino)-2-Oxoacetate Hydrochloride, a vital component in anticoagulant drug manufacturing.
- Learn about the synthesis of coagulation factor Xa inhibitors, a crucial area in cardiovascular drug development.
- Discover the importance of this pharmaceutical intermediate in developing treatments for conditions like deep vein thrombosis.
Advantages
Efficient Synthesis
The pharmaceutical chemical manufacturing process described here is optimized for efficiency and yield, supporting large-scale production needs.
Scalable Production
This method is designed for chemical synthesis of anticoagulants on an industrial scale, ensuring reliable supply.
High Purity Product
Achieve high chiral purity for your cardiovascular health APIs, meeting stringent pharmaceutical standards.
Key Applications
Anticoagulant Therapy
Utilize this intermediate for the development of advanced anticoagulant therapies, critical for managing various cardiovascular conditions.
Thrombosis Prevention
Key in producing drugs for effective thrombosis prevention, safeguarding patients from potentially life-threatening blood clots.
Stroke Prevention
Contributes to the creation of pharmaceuticals for stroke prevention in patients with conditions like atrial fibrillation.
Pulmonary Embolism Treatment
Essential for manufacturing treatments for pulmonary embolism, a serious condition affecting the lungs.