Fmoc-L-Alanine (CAS 35661-39-3): The Backbone of Modern Peptide Synthesis
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Fmoc-L-Alanine
Fmoc-L-Alanine (CAS 35661-39-3) is an indispensable reagent in the field of peptide synthesis, particularly for solid-phase peptide synthesis (SPPS). Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group offers a milder and more orthogonal de-protection strategy compared to traditional methods, making it a preferred choice for complex peptide sequences and sensitive amino acid modifications. This product is essential for achieving high peptide yield and purity in both academic research and industrial applications, including drug development.
- Facilitate efficient peptide chain elongation using this key building block for your solid phase peptide synthesis projects.
- Leverage the advantages of Fmoc chemistry for milder reaction conditions and easier purification processes.
- Ensure the success of your proteomics studies with a reliably pure and high-quality amino acid derivative.
- Explore the pharmaceutical applications of Fmoc-L-Alanine in the development of novel peptide-based therapeutics.
Key Advantages
Milder Synthesis Conditions
The ease of Fmoc group removal with a weak base, such as piperidine, allows for milder reaction conditions compared to acid-labile protecting groups, preserving peptide integrity.
Orthogonal Protection Strategy
Fmoc chemistry provides a true side-chain protecting group orthogonality, ensuring selective deprotection and minimizing unwanted side reactions during synthesis.
Enhanced Purity and Yield
Utilizing high-purity Fmoc-L-Alanine significantly contributes to higher peptide yields and purer crude peptides, simplifying downstream purification and reducing synthesis failures.
Key Applications
Peptide Synthesis
As a fundamental building block, Fmoc-L-Alanine is crucial for the step-by-step assembly of peptide chains in solid phase peptide synthesis.
Proteomics Research
Its role in peptide synthesis makes it invaluable for creating peptides used in proteomics studies, aiding in the understanding of protein function and interactions.
Drug Development
Fmoc-L-Alanine is widely employed in the pharmaceutical industry for the synthesis of peptide-based therapeutics and drug candidates.
Organic Synthesis
Beyond peptides, this derivative finds application in various organic synthesis pathways requiring protected amino acids.