Fmoc-(S)-3-Amino-4-(3,4-difluorophenyl)butyric Acid: Advancing Peptide Synthesis

Unlock the potential of advanced peptide design with this critical unnatural amino acid building block.

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Key Advantages

Enhanced Biological Activity

The strategic incorporation of the difluorophenyl group in this amino acid derivative is known to significantly boost the biological activity of the resulting peptides, making them more potent and effective for therapeutic applications.

Improved Metabolic Stability

Fluorination often leads to increased resistance against enzymatic degradation. This means peptides synthesized using this building block can exhibit longer half-lives in vivo, a critical factor for drug efficacy.

Versatile Peptide Synthesis Intermediate

With the reliable Fmoc protecting group, this compound is perfectly suited for solid-phase peptide synthesis (SPPS), allowing for controlled and sequential coupling of amino acids to build complex peptide chains efficiently.

Key Applications

Peptide Synthesis

A fundamental component for the construction of peptides in research and development, supporting the synthesis of complex and modified peptide sequences.

Drug Discovery

Crucial for creating novel drug candidates, particularly those targeting diseases where peptide-based therapeutics show promise.

Medicinal Chemistry

Enables chemists to explore the impact of fluorinated amino acid residues on drug efficacy, pharmacokinetics, and pharmacodynamics.

Chemical Synthesis

Serves as a valuable building block in broader organic synthesis applications requiring chiral and fluorinated moieties.