Fructose-1,6-diphosphate (CAS 488-69-7): Mechanism of Action and Anti-inflammatory Effects in Arthritis

Discover how Fructose-1,6-diphosphate, a key glycolytic intermediate, offers potent anti-inflammatory benefits by modulating adenosine pathways, presenting a novel therapeutic avenue for inflammatory diseases.

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Key Advantages

Potent Anti-inflammatory Action

Fructose-1,6-diphosphate exhibits a significant reduction in joint inflammation, hyperalgesia, and swelling, contributing to its effectiveness in arthritis treatment.

Adenosine Pathway Modulation

The compound's ability to activate the anti-inflammatory adenosinergic pathway, particularly through the A2a receptor, highlights its sophisticated mechanism of action.

Metabolic Intermediate Role

As a key intermediate of glycolysis, FBP plays a crucial role in cellular energy metabolism, sustaining glycolysis and increasing ATP production, which supports overall tissue health.

Key Applications

Arthritis Treatment

Leverage FBP for its anti-inflammatory benefits in managing arthritis symptoms, offering a novel therapeutic strategy.

Ischemic Injury Mitigation

FBP's role in sustaining glycolysis and ATP production provides protective effects in various ischemic injury models.

Metabolic Support

The compound's involvement in glucose metabolism makes it relevant for conditions where metabolic regulation is critical.

Cardiovascular Health

Research suggests FBP's potential in aiding cardiovascular conditions, particularly those related to myocardial ischemia.