High-Grade PVP K90: Properties and Pharmaceutical Applications
Discover the versatility of Polyvinylpyrrolidone (PVP) K90, a key excipient in modern pharmaceuticals and beyond.
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Polyvinylpyrrolidone K90
Polyvinylpyrrolidone (PVP), also known as povidone, is a water-soluble polymer with remarkable versatility, particularly valued in the pharmaceutical industry. Its synthesis from N-vinylpyrrolidone monomer under catalytic action results in a white to milky, odorless, and tasteless powder that is hygroscopic. This high-grade PVP K90 serves as a critical component in numerous formulations, leveraging its unique chemical and physical properties.
- PVP K90 as a crucial dissolution enhancer significantly improves the solubility of poorly soluble drugs, facilitating more effective drug delivery.
- It functions as an excellent tablet binder, ensuring the integrity and consistency of solid dosage forms in pharmaceutical manufacturing.
- Its properties as a suspending agent aid in maintaining the uniform distribution of particles in liquid formulations, preventing sedimentation.
- As a disintegrant, PVP K90 helps tablets break down effectively after administration, promoting drug release.
- This polymer finds extensive use in medical applications, notably in the formulation of povidone-iodine complexes, known for their disinfectant properties.
Key Advantages and Benefits
Exceptional Solubility and Compatibility
The ability of PVP K90 to enhance drug solubility makes it invaluable for formulating challenging active pharmaceutical ingredients.
Versatile Pharmaceutical Excipient
Its role as a pharmaceutical excipient is broad, acting as a binder, suspending agent, and dissolution enhancer for various dosage forms.
Broad Application Spectrum
Beyond pharmaceuticals, PVP K90 is utilized in technical fields, contact lenses, and medical solutions, showcasing its wide-ranging utility and good biological compatibility.
Key Applications
Pharmaceutical Formulations
Utilized as a binder, disintegrant, and dissolution enhancer for tablets, capsules, and suspensions, aiding in the effective delivery of active pharmaceutical ingredients.
Medical Solutions
Forms complexes like povidone-iodine, widely used as an antiseptic and disinfectant in medical settings.
Contact Lenses
Acts as a lubricant and wetting agent in contact lens solutions, enhancing comfort and reducing friction.
Technical and Industrial Uses
Employed in diverse industrial applications, including inks, coatings, and as a dispersing agent.