L-2-Aminobutyric Acid: Properties, Applications, and Industrial Production Insights
Discover the versatility of L-2-Aminobutyric Acid as a pharmaceutical intermediate, produced efficiently through advanced fermentation techniques.
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L-2-Aminobutyric Acid
L-2-Aminobutyric Acid (L-ABA) is a crucial unnatural amino acid that serves as a key intermediate in the synthesis of numerous pharmaceuticals. Its unique structure and properties make it indispensable for creating vital drugs used in treating conditions ranging from epilepsy to tuberculosis, as highlighted in research on the bioproduction of chiral drugs.
- Precise Specifications for Pharmaceutical Use: Offers high purity (Assay 98.5%～101.0%) and specific optical rotation ([α]D20 +20.2°～+23.0°), ensuring reliability in sensitive synthesis processes.
- Enhanced Production via Metabolic Engineering: Advanced techniques in metabolic engineering and fermentation, particularly using modified Escherichia coli strains, enable sustainable and efficient industrial-scale production, addressing the growing demand for unnatural amino acid biosynthesis.
- Foundation for Critical Pharmaceuticals: Acts as a vital precursor for drugs like Levetiracetam (anti-epileptic) and Ethambutol (anti-tuberculotic), underscoring its significance in the healthcare sector.
- Role in Biochemical Pathways: Its metabolism is closely linked to amino acid catabolism and can reflect changes in cellular redox states, making it a subject of interest in amino acid metabolism research.
Key Advantages
Cost-Effective & Sustainable Production
Leveraging metabolic engineering and fermentation processes, L-2-Aminobutyric Acid production is optimized for cost-effectiveness and environmental sustainability, a key aspect of unnatural amino acid biosynthesis.
High Purity and Specificity
The production process ensures high purity and stereochemical specificity, crucial for its application as a pharmaceutical intermediate in complex synthetic routes.
Versatile Application Range
Beyond direct pharmaceutical synthesis, L-2-Aminobutyric Acid is valuable in biochemical research and as a chiral reagent, contributing to various scientific advancements and the bioproduction of chiral drugs.
Key Applications
Pharmaceutical Synthesis
An essential building block for synthesizing critical drugs, demonstrating its importance in the field of pharmaceutical intermediate manufacturing.
Biochemical Research
Used in studies exploring amino acid metabolism, redox balance, and enzyme kinetics, contributing to fundamental biological understanding.
Drug Intermediate Development
Its role as a precursor highlights its value in the ongoing development and production of new therapeutic agents.
Chiral Reagent
Its specific chirality makes it useful in asymmetric synthesis and other chemical applications requiring stereochemical control.
Related Technical Articles & Resources
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