N-Azidoacetylgalactosamine-tetraacylated: Advancing Glycobiology Research

A key unnatural monosaccharide for sophisticated metabolic labeling and glycoprotein detection.

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Key Advantages of This Reagent

Enhanced Cell Permeability

The acetyl groups on Ac4GalNAz significantly increase its solubility in organic solvents and improve its ability to pass through cell membranes, a key factor in successful metabolic labeling.

Versatile Click Chemistry Compatibility

The azide functional group on this unnatural sugar is compatible with both copper-catalyzed (CuAAC) and copper-free click reactions, offering flexibility in detection strategies.

Streamlined Glycoprotein Analysis

By incorporating Ac4GalNAz and subsequently applying click chemistry with fluorescent or biotinylated alkynes, researchers can effectively visualize and analyze modified glycoproteins.

Key Applications

Glycobiology Research

Investigate cellular glycosylation pathways and understand the roles of specific glycans using this reagent for metabolic labeling and subsequent analysis.

Bioconjugation

Utilize the azide handle for conjugation with various molecules, such as fluorescent dyes or affinity tags, through robust click chemistry reactions.

Proteomics and Glycomics

Aid in the identification and characterization of glycoproteins and their modifications, contributing to advancements in proteomics and glycomics.

Drug Delivery and Imaging

Explore potential applications in developing novel drug delivery systems or imaging agents that target specific cellular glycans.