N-Cbz-L-Histidine Hydrazide: A Versatile Building Block for Peptide Synthesis
Explore advanced peptide chemistry with our high-purity N-Cbz-L-histidine hydrazide, a key intermediate for novel therapeutic discovery.
Get a Quote & SampleProduct Core Value
N-Cbz-L-Histidine Hydrazide
N-Cbz-L-histidine hydrazide serves as a crucial intermediate in peptide synthesis, facilitating the creation of complex peptide structures. Its unique chemical handle allows for late-stage diversification, enabling the conversion to peptide acids or amides, which are vital for optimizing peptide drug properties. This product supports advanced peptide chemistry, offering a pathway to novel therapeutic agents.
- Enabling Late-Stage Peptide Diversification: This compound is instrumental in transforming peptide hydrazides into peptide acids or amides, offering significant flexibility in drug discovery workflows.
- Compatibility with Oxidation-Prone Amino Acids: Unlike some methods, the transformations utilizing this building block are compatible with sensitive amino acids like Cys, Met, and Trp, ensuring broader applicability in peptide synthesis.
- Streamlined Synthesis Protocols: The article details practical protocols for converting hydrazides to acids and amides, reducing the overall synthetic steps required compared to traditional double SPPS approaches.
- Discovery of Potent Antimicrobials: Research indicates that peptide hydrazides, such as derivatives of this compound, can exhibit enhanced antimicrobial activity, opening new avenues for developing antibacterial agents.
Key Advantages
Enhanced Versatility
The ability to convert N-Cbz-L-histidine hydrazide to both peptide acids and amides provides researchers with versatile options for structure-activity relationship studies in drug discovery chemistry.
Improved Peptide Stability
Hydrazide modifications have been hypothesized to improve peptide stability against enzymatic degradation, potentially leading to enhanced therapeutic efficacy and longer shelf life.
Facilitated Library Synthesis
This building block is key for efficient solid-phase peptide synthesis, allowing for the creation of diverse peptide libraries for screening and lead optimization in the field of peptide therapeutics.
Key Applications
Peptide Synthesis Reagents
Essential component for synthesizing a wide range of peptides, including complex sequences and modified peptides, crucial for amino acid building blocks research.
Drug Discovery
Facilitates the exploration of novel peptide-based drug candidates by enabling late-stage modifications to optimize pharmacological properties and bioavailability.
Chemical Synthesis
A valuable tool in organic synthesis for researchers developing new chemical methodologies and creating diverse molecular structures.
Antimicrobial Peptide Research
Its derivatives have shown potent antimicrobial activity, making it a focus for research into new treatments for bacterial infections, a key area in antimicrobial peptide research.