N-Methyl-4-piperidinol: A Key Intermediate for Pharmaceutical Synthesis
Discover the crucial role of N-Methyl-4-piperidinol in producing vital pharmaceuticals and its broader applications.
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N-Methyl-4-piperidinol
N-Methyl-4-piperidinol (CAS No. 106-52-5) is a critical chemical compound widely recognized for its indispensable role as an intermediate in the synthesis of Loratadine, a widely used antihistamine. Its precise chemical structure and high purity levels make it a preferred choice in pharmaceutical manufacturing. The compound's physical characteristics include being a colorless to light yellow liquid or solid with a defined melting point of 29-31°C and a boiling point of 200°C, ensuring consistency in chemical processes. With an assay of ≥98.0%, it meets stringent quality standards for pharmaceutical applications.
- Understanding the CAS 106-52-5 chemical properties is vital for efficient pharmaceutical synthesis, ensuring optimal reaction conditions and product yield.
- The synthesis of N-Methyl-4-piperidinol often involves sophisticated chemical processes, requiring specialized knowledge and equipment to achieve high purity.
- Exploring the applications of N-Methyl-4-piperidinol in pharmaceuticals reveals its significance beyond Loratadine, contributing to the development of new therapeutic agents.
- Sourcing N-Methyl-4-piperidinol suppliers globally provides access to reliable manufacturers who adhere to strict quality control measures for API intermediate production.
Key Advantages
Enhanced Pharmaceutical Efficacy
Leveraging N-Methyl-4-piperidinol as a key intermediate for Loratadine synthesis contributes significantly to the efficacy and safety of the final drug product, ensuring reliable therapeutic outcomes.
Versatile Chemical Reactant
Beyond its primary use, this compound serves as a versatile chemical reactant for novel drug discovery, aiding in the creation of advanced therapeutic agents and complex molecular structures.
Guaranteed High Purity
The availability of N-Methyl-4-piperidinol with an assay of ≥98.0% ensures that crucial chemical synthesis steps meet rigorous pharmaceutical quality standards, minimizing impurities.
Key Applications
Loratadine Synthesis
As a principal intermediate, N-Methyl-4-piperidinol is fundamental to the efficient and scalable production of Loratadine, a widely prescribed non-sedating antihistamine.
Antitumor Agents
Research indicates its utility as a reactant in optimizing molecular scaffolds, such as the Novobiocin scaffold, for the development of potent antitumor agents.
Kinase Inhibitors
The compound is utilized in the synthesis of critical drug candidates targeting kinases, including VEGFR and FGFR kinase inhibitors, crucial in cancer therapy research.
Histamine H4 Receptor Antagonists
Its structural features make it valuable in the design and synthesis of histamine H4 receptor antagonists, which have potential applications in inflammatory and immune-related disorders.
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