Polyvinylpyrrolidone K25: A Versatile Pharmaceutical Excipient
Enhancing drug delivery with a high-performance binder and solubilizer.
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Polyvinylpyrrolidone K25
Polyvinylpyrrolidone K25 is a crucial pharmaceutical excipient renowned for its exceptional versatility. It serves as a highly effective binder in tablet formulations, enhancing mechanical strength and compressibility. Furthermore, its ability to improve the solubility of poorly soluble drugs significantly boosts bioavailability, a key factor in therapeutic efficacy. Its film-forming capabilities are vital for coatings, while its stabilizing properties ensure the integrity of various liquid and semi-liquid preparations.
- As a reliable tablet binder, Polyvinylpyrrolidone K25 offers excellent tablet binding capacity at low concentrations, producing hard, non-friable tablets, thus meeting the demands for robust oral solid dosage forms.
- The excellent solubility in water and non-polar solvents allows Polyvinylpyrrolidone K25 to be added as an aqueous or non-aqueous solution to wet granulation tablet processes, providing formulators with flexibility.
- Its low solution viscosity ensures easy processing, as workable solution viscosity at high polymer levels makes it easy to use in granulation and other manufacturing equipment.
- As a drug solubilizer, Polyvinylpyrrolidone K25 inhibits crystallization of drug actives and stabilizes suspensions, dispersions, and emulsions, contributing to improved drug product performance.
Key Advantages Offered
Enhanced Tablet Properties
Leveraging the strong adhesive strength of Polyvinylpyrrolidone K25, formulators can achieve tablets with superior hardness and reduced friability, ensuring consistent drug delivery.
Improved Drug Dissolution
The unique properties of Polyvinylpyrrolidone K25 act as a coprecipitating agent, significantly enhancing the solubility and dissolution rate of insoluble drugs, thereby increasing bioavailability.
Formulation Flexibility
With excellent solubility in a wide range of solvents, Polyvinylpyrrolidone K25 offers immense flexibility in formulation design, accommodating various processing needs and drug sensitivities.
Key Applications
Tablet Manufacturing
Polyvinylpyrrolidone K25 is extensively used as a binder in tablet formulations, aiding in granulation processes and improving tablet compressibility and mechanical strength.
Drug Solubilization
It functions as a solubilizer for poorly soluble drugs, enhancing their dissolution rates and improving overall bioavailability for more effective therapeutic outcomes.
Film Coating
The excellent film-forming capacity of Polyvinylpyrrolidone K25 makes it ideal for coating applications, providing protective layers and aiding in the dispersion of pigments.
Liquid & Semi-Liquid Preparations
PVP K25 serves as a stabilizer and thickener in various liquid and semi-liquid preparations, including injections and ophthalmic solutions, ensuring product stability and efficacy.