Unlocking Nebivolol Hydrochloride: The Key Role of (R)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic Acid
Discover the critical intermediate for advanced antihypertensive drug synthesis. Explore its properties and applications.
Get a Quote & SampleProduct Core Value
(R)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic Acid
This enantiomerically pure compound serves as a vital building block in the complex synthesis of Nebivolol hydrochloride, a leading pharmaceutical agent for treating hypertension. Its precise chemical structure and high purity are essential for ensuring the efficacy and safety of the final drug product.
- Leverage the power of precise pharmaceutical intermediates for antihypertensives with this high-purity compound.
- Optimize your drug synthesis pathways by utilizing key chromene derivatives in drug synthesis.
- Understand the critical CAS 129101-37-7 chemical properties for efficient API manufacturing.
- Ensure product integrity with a reliable nebivolol hydrochloride precursor manufacturing solution.
Advantages of Using This Intermediate
Chiral Purity
The specific (R)-configuration of this compound is crucial for the stereospecific synthesis of Nebivolol, directly impacting the drug's therapeutic activity and reducing potential side effects. This makes it a key component in chiral intermediates for cardiovascular drugs.
Synthesis Efficiency
As a high-purity intermediate, it streamlines the Nebivolol hydrochloride synthesis process, potentially reducing reaction steps and improving overall yield, contributing to more effective API intermediate production.
Chemical Stability
With a density of 1.364 g/cm³ and a flash point of 170.3°C, this compound offers good handling and storage characteristics. Proper storage in a cool, dry, well-ventilated area away from incompatible substances ensures its quality for complex fluorinated benzopyran derivatives for pharmaceuticals.
Key Applications
Nebivolol Hydrochloride Synthesis
This compound is the primary precursor for synthesizing Nebivolol hydrochloride, a vital beta-blocker used globally for managing hypertension. Its reliable supply is critical for pharmaceutical manufacturers. This is a core aspect of pharmaceutical intermediates for antihypertensives.
API Manufacturing
As a high-grade API intermediate, it is essential for Active Pharmaceutical Ingredient production, requiring stringent quality control and adherence to regulatory standards.
Chiral Synthesis
The compound's inherent chirality makes it valuable in stereoselective synthesis processes, particularly for complex molecules like Nebivolol, highlighting its role in chiral building blocks for pharmaceuticals.
Research and Development
Used in R&D for exploring new synthetic routes or developing related pharmaceutical compounds, further utilizing its unique structural features as a fluorinated chromene derivative.