Temozolomide (CAS 85622-93-1): A Comprehensive Guide to its Chemical Properties, Applications, and Research Significance
Discover the science behind Temozolomide, a key player in brain cancer treatment and oncology research.
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Temozolomide
Temozolomide is a highly effective alkylating agent crucial in the treatment of various brain cancers. Its ability to induce apoptosis by alkylating DNA, particularly guanine residues, makes it a cornerstone in modern oncology. Research into its mechanism, including its interaction with the MGMT gene and potential for combination therapies, continues to expand its therapeutic horizons.
- Temozolomide mechanism of action involves DNA alkylation, specifically methylating guanine, which leads to cancer cell death and apoptosis.
- Temozolomide for brain cancer treatment, including glioblastoma and anaplastic astrocytoma, highlights its specialized therapeutic application.
- Understanding Temozolomide drug interactions is vital for safe and effective patient management, requiring careful consideration of concomitant medications.
- The study of Temozolomide MGMT gene interaction is key to predicting patient response and overcoming drug resistance in cancer therapy.
Key Advantages
Targeted Cancer Therapy
Leveraging its Temozolomide mechanism of action, this compound offers targeted therapy for specific brain cancers, minimizing damage to healthy cells where possible.
Research & Development Potential
Ongoing Temozolomide research applications explore novel combinations and strategies to enhance efficacy and combat resistance, driving innovation in cancer treatment.
Chemical Versatility
With its well-defined Temozolomide chemical properties, it serves as a valuable compound for further chemical synthesis and development in pharmaceutical research.
Key Applications
Oncology Drug Research
Exploring the Temozolomide mechanism of action and its role in DNA damage response pathways for new drug development.
Brain Tumor Therapeutics
Utilizing Temozolomide as a primary or adjunct treatment for various brain tumors, based on Temozolomide for brain cancer indications.
Pharmaceutical Intermediate
Serving as a key intermediate in the synthesis of advanced pharmaceutical compounds and derivatives.
Drug Resistance Studies
Investigating mechanisms of resistance, such as those related to the Temozolomide MGMT gene, to develop more effective treatment strategies.