Understanding tert-Butyl (4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
Your essential guide to a key component in modern pharmaceutical synthesis.
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tert-Butyl (4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
This compound is a vital intermediate in the synthesis of HMG-CoA reductase inhibitors, most notably Atorvastatin. Its precise stereochemistry is critical for the efficacy of the final drug product, making its reliable production and sourcing paramount in the pharmaceutical industry.
- Key intermediate for Atorvastatin synthesis, a widely prescribed cholesterol-lowering medication.
- Critical role in HMG-CoA reductase inhibitor production, impacting cardiovascular health treatments.
- Specific stereochemistry (4R,6R) ensures targeted biological activity of the final pharmaceutical.
- High purity levels (≥99.0%) are essential for meeting stringent pharmaceutical manufacturing standards.
Advantages Provided by the Product
Enhanced Drug Efficacy
The precise chiral centers within this compound contribute to the effectiveness of Atorvastatin, supporting its role in managing high cholesterol levels effectively.
Streamlined Synthesis
Utilizing this intermediate simplifies the complex chemical synthesis of statins, reducing production steps and potentially lowering manufacturing costs.
Quality Assurance
Sourcing high-purity intermediates like tert-Butyl (4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate (CAS 125995-13-3) ensures the final drug meets all regulatory and quality requirements.
Key Applications
Atorvastatin Synthesis
This compound serves as a foundational building block in the multi-step synthesis of Atorvastatin, a blockbuster drug for hypercholesterolemia.
Other Statin Drugs
Its structural features make it a valuable intermediate for research and development of other statin-class drugs targeting cholesterol metabolism.
Pharmaceutical Research
Used in laboratories for method development and process optimization in the pharmaceutical industry.
Advanced Chemical Intermediates
Its utility extends to the synthesis of other complex organic molecules requiring specific chiral functionalities.