Tris(hydroxymethyl)aminomethane: A Versatile Pharmaceutical Intermediate and Biological Buffer
Essential for biochemical research and pharmaceutical synthesis, offering stable pH control and broad industrial applications.
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Tris(hydroxymethyl)aminomethane
Tris(hydroxymethyl)aminomethane, commonly known as Trometamol or Tris Base, is a white crystalline powder with a melting point of 167-172°C. Its high solubility in water and ethanol makes it exceptionally versatile for various applications. It is indispensable as a biological buffer, crucial for maintaining stable pH levels in biochemistry and molecular biology experiments, particularly in the pH range of 7.0-9.0. This makes it ideal for nucleic acid and protein solutions, electrophoresis, and enzyme assays, aiding in groundbreaking scientific research.
- As a key pharmaceutical intermediate, Tris(hydroxymethyl)aminomethane is vital for synthesizing a range of important drugs, contributing to advancements in healthcare.
- Tris buffer for DNA extraction and other molecular biology applications ensures reliable experimental outcomes by providing consistent pH environments.
- Its role as a pH regulator extends to cosmetics and personal care products, where it stabilizes formulations and enhances product efficacy.
- Tris hydroxymethyl aminomethane is also utilized in the production of surfactants and vulcanization accelerators, demonstrating its broad industrial utility.
Key Advantages
Versatile pH Buffering
Tris buffer pH range between 7.0-9.0 is optimal for many biological and biochemical reactions, making it a staple in research laboratories.
Pharmaceutical Synthesis
Its function as a pharmaceutical intermediate for drugs like ketorolac tromethamine and fosfomycin tromethamine highlights its critical role in healthcare manufacturing.
Broad Industrial Applicability
Beyond biology and medicine, Tris hydroxymethyl aminomethane finds use in diverse sectors including coatings, inks, and activated carbon modification.
Key Applications
Biochemistry and Molecular Biology
Used extensively in buffer solutions for electrophoresis, DNA/RNA isolation, and enzyme assays, ensuring accurate experimental results.
Pharmaceutical Manufacturing
Serves as a critical intermediate in the synthesis of various pharmaceutical compounds, contributing to drug development and production.
Cosmetics and Personal Care
Acts as a pH adjuster and stabilizer in cosmetic formulations, enhancing product efficacy and shelf life.
Industrial Chemicals
Found in the production of surfactants, vulcanization accelerators, and modified activated carbon, showcasing its versatility.