Understanding Digoxin: A Comprehensive Guide to its Properties and Applications
Explore the critical role of Digoxin in cardiac treatment and pharmaceutical research.
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Digoxin
Digoxin, identified by CAS number 20830-75-5, is a potent cardiac glycoside sourced from Digitalis lanata. It plays a vital role in managing cardiac arrhythmias by effectively inhibiting the Na+/K+-ATPase pump, a crucial mechanism for maintaining cellular ion balance.
- Leveraging Digoxin CAS 20830-75-5 for Cardiac Arrhythmia Treatment: This compound's ability to modulate ion channels makes it essential for stabilizing heart rhythm.
- Utilizing Digoxin as a P-glycoprotein Model Substrate: Researchers frequently employ this pharmaceutical intermediate in studies investigating P-glycoprotein activity and drug transport.
- Understanding the Mechanism of Na+/K+-ATPase Inhibition by Digoxin: Its specific action on this enzyme is key to its therapeutic effects and further pharmacological research.
- Exploring the Pharmaceutical Applications of Digitalis Lanata-derived Digoxin: As a key compound from this plant, it highlights the significance of natural product chemistry in medicine.
Key Advantages Offered
Cardiac Rhythm Stabilization
The precise inhibition of the Na+/K+-ATPase pump by Digoxin directly contributes to stabilizing irregular heart rhythms, a critical benefit for patients with cardiovascular conditions.
Advancement in Drug Transport Research
Its established role as a P-glycoprotein model substrate facilitates deeper understanding of drug absorption, distribution, metabolism, and excretion (ADME) properties.
Pharmacological Insight Generation
Studying Digoxin’s interaction with key cellular pumps provides valuable insights into the fundamental mechanisms of cardiovascular drug action.
Key Applications
Cardiac Arrhythmia Management
Digoxin is a cornerstone therapy for various cardiac arrhythmias, helping to restore and maintain a regular heartbeat.
Pharmacokinetic Studies
Its use as a benchmark compound in studies related to drug transporters, particularly P-glycoprotein, aids in predicting drug behavior in the body.
Biochemical Research
Researchers utilize Digoxin to investigate the intricate workings of ion-motive ATPases and their role in cellular function.
Reference Standards Development
High-purity Digoxin serves as an essential reference material for quality control and analytical method development in the pharmaceutical industry.