Hydroxypropyl Methyl Cellulose Phthalate (HPMC-P) HP55: Your Key Pharmaceutical Excipient
Discover the versatility and benefits of HPMC-P HP55 for advanced pharmaceutical formulations and drug delivery.
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Hydroxypropyl Methyl Cellulose Phthalate HP55
This white to off-white powder is a vital pharmaceutical excipient known for its excellent enteric coating properties and as a tablet diluent and disintegrant. Its pH-dependent solubility, specifically its insolubility at pH 5.0-5.5 and dissolution in the upper intestine, makes it ideal for controlled drug release.
- Leveraging HPMC-P HP55 for superior enteric coating ensures drugs are protected from stomach acid and released in the optimal part of the intestine.
- Utilize HPMC-P HP55 as a tablet diluent to provide bulk and aid in the manufacturing of tablets, improving overall formulation efficiency.
- Explore the benefits of HPMC-P HP55 as a tablet disintegrant, facilitating the rapid breakdown of tablets in the gastrointestinal tract for enhanced drug absorption.
- Investigate the application of HPMC-P HP55 in amorphous solid dispersions to improve the solubility and bioavailability of poorly soluble active pharmaceutical ingredients.
Key Advantages
Targeted Drug Release
The pH-dependent solubility of Hydroxypropyl Methyl Cellulose Phthalate HP55 allows for precise control over drug release, targeting specific sections of the gastrointestinal tract for improved therapeutic outcomes.
Enhanced Formulation Stability
As a reliable pharmaceutical excipient, HPMC-P HP55 contributes to the physical and chemical stability of dosage forms, ensuring product integrity throughout its shelf life.
Versatile Application
Beyond enteric coating, HPMC-P HP55 serves effectively as a diluent and disintegrant, demonstrating its versatility in various tablet formulations and drug delivery systems like solid dispersions.
Key Applications
Enteric Coating
Provide gastric protection and targeted release in the small intestine, a critical function enabled by HPMC-P HP55's pH solubility.
Tablet Formulation
Serve as an effective tablet diluent and disintegrant, enhancing manufacturing processes and drug dissolution rates.
Amorphous Solid Dispersions
Improve the bioavailability of challenging APIs by acting as a matrix for solid dispersions, a key area for modern drug development.
Microencapsulation
Create protective shells for active ingredients, ensuring stability and controlled release through specialized microencapsulation techniques.