ZSTK474: A Potent PI3K Inhibitor for Cancer Research and Therapeutic Development
Explore the groundbreaking potential of ZSTK474, a leading PI3K inhibitor with significant therapeutic promise.
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ZSTK474
ZSTK474 stands out as a highly potent and selective inhibitor targeting all four isoforms of class I PI 3-kinase. Its efficacy is notably superior to existing inhibitors like LY294002, offering a more favorable therapeutic profile with reduced toxicity. The compound has demonstrated significant anti-tumor activity across a range of preclinical cancer models, showcasing its potential in halting cell growth, inhibiting osteoclast formation, and exhibiting promise as a targeted therapy for challenging diseases like sarcoma.
- Discover the molecular mechanisms behind ZSTK474's anti-tumor activity and its impact on the PI3K pathway.
- Learn about the in vivo study results, highlighting ZSTK474's efficacy in animal models and its potential as a sarcoma targeted therapy.
- Understand how ZSTK474 functions as a leading PI3K pathway inhibitor in the realm of oncology drug discovery.
- Explore the chemical properties and applications of ZSTK474 as a crucial pharmaceutical intermediate for advanced cancer research.
Advantages of ZSTK474
Enhanced Potency and Selectivity
ZSTK474 offers unparalleled potency and selectivity against PI3K isoforms, outperforming traditional PI3K inhibitor options and leading to more effective therapeutic outcomes.
Demonstrated Anti-Tumor Activity
Preclinical studies consistently show ZSTK474's ability to inhibit tumor growth, arrest cell proliferation, and even induce apoptosis in specific cancer types, underscoring its role in targeted cancer therapy development.
Favorable Safety Profile
Compared to earlier generation inhibitors, ZSTK474 presents a reduced toxicity profile, making it a more attractive candidate for further clinical development and long-term patient treatment.
Key Applications
Oncology Research
Investigate the intricate workings of the PI3K pathway and develop novel therapeutic strategies for various cancers using ZSTK474 as a crucial research tool.
Pharmaceutical Development
Advance drug discovery pipelines with ZSTK474, a high-quality pharmaceutical intermediate vital for creating next-generation cancer therapeutics.
Sarcoma Treatment
Explore the specific antitumor effects of ZSTK474 in sarcoma models, paving the way for targeted sarcoma treatment options.
Inhibitor Studies
Utilize ZSTK474 for in-depth studies on PI3K inhibition, understanding its impact on cellular processes and disease progression.