5-Fluoro-2-nitrophenol: A Versatile Chemical Compound
5-Fluoro-2-nitrophenol is a chemical compound with the molecular formula C6H4FNO3. It is also known as 3-Fluoro-6-nitrophenol or 4-fluoro-2-hydroxy-1-nitrobenzene. The chemical structure of the compound consists of a nitro group (-NO2) and a hydroxy group (-OH) attached to a benzene ring, with a fluorine atom (-F) substituted at the second position of the ring. The compound has a molecular weight of 155.1 g/mol and a melting point of 107-109°C.
The synthesis of 5-Fluoro-2-nitrophenol involves the reaction of 2-fluoro-4-nitrophenol with a suitable reagent, such as sodium hydroxide or potassium carbonate, under appropriate conditions. The compound is a yellow crystalline solid that is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone.
Applications of 5-Fluoro-2-nitrophenol
5-Fluoro-2-nitrophenol has a wide range of applications in various industries, including pharmaceuticals, agrochemicals, and materials science. Some of the major applications of the compound are discussed below.
Pharmaceuticals
The pharmaceutical industry is one of the major users of 5-Fluoro-2-nitrophenol. The compound is used as a key intermediate in the synthesis of various pharmaceuticals, including antiviral, anticancer, and anti-inflammatory drugs. For example, 5-Fluoro-2-nitrophenol is a precursor for the synthesis of the antiviral drug entecavir, which is used for the treatment of chronic hepatitis B virus infection. The compound is also used in the synthesis of the anticancer drug sorafenib, which is used for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma.
Agrochemicals
5-Fluoro-2-nitrophenol is also used in the production of agrochemicals, such as herbicides and insecticides. The compound is a precursor for the synthesis of various agrochemicals, including the herbicide flumioxazin and the insecticide flonicamid. Flumioxazin is a broad-spectrum herbicide that is used for the control of weeds in crops such as soybeans, peanuts, and cotton. Flonicamid is an insecticide that is used for the control of various pests, including aphids and whiteflies, in crops such as vegetables, fruits, and ornamentals.
Materials Science
In addition to its applications in the pharmaceutical and agrochemical industries, 5-Fluoro-2-nitrophenol is also used in materials science. The compound is used as a building block for the synthesis of various materials, including polymers, liquid crystals, and functional materials. For example, the compound is used as a monomer for the synthesis of fluorinated polymers, which are used in various applications such as coatings, adhesives, and membranes. The compound is also used as a precursor for the synthesis of liquid crystals, which are used in various applications such as displays, sensors, and optical devices.
Conclusion
In conclusion, 5-Fluoro-2-nitrophenol is a versatile chemical compound with a wide range of applications in various industries. The compound is used as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and materials. Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer and supplier of 5-Fluoro-2-nitrophenol from China. With its high-quality products and reliable services, the company has established a strong reputation in the global chemical market.
