4-Amino-3-nitrophenol: Properties, Applications, and Production
4-Amino-3-nitrophenol, also known as 3-Nitro-4-aminophenol, is an organic compound with the chemical formula C6H6N2O3. It is a yellow crystalline powder that is widely used in the production of dyes, pigments, and pharmaceuticals. In this article, we will explore the properties, applications, and production of 4-Amino-3-nitrophenol.
Properties of 4-Amino-3-nitrophenol
4-Amino-3-nitrophenol is a yellow crystalline powder that is sparingly soluble in water but soluble in organic solvents such as ethanol, methanol, and acetone. It has a melting point of 157-160°C and a boiling point of 414.7°C at 760 mmHg. The compound has a pKa value of 7.48, indicating that it is a weak acid.
Applications of 4-Amino-3-nitrophenol
4-Amino-3-nitrophenol is a versatile compound that finds application in various industries. Some of the major applications of 4-Amino-3-nitrophenol are:
1. Dye and Pigment Industry
4-Amino-3-nitrophenol is used in the production of various dyes and pigments, including acid dyes, azo dyes, and disperse dyes. The compound is used as a diazotizing agent to synthesize azo dyes, which are widely used in the textile industry. It is also used as a coupling agent to produce various color shades in acid dye formulations.
2. Pharmaceutical Industry
4-Amino-3-nitrophenol is used as an intermediate in the synthesis of various pharmaceuticals, including analgesics, antipyretics, and anti-inflammatory drugs. It is used as a starting material to synthesize paracetamol, which is a widely used analgesic and antipyretic drug.
3. Organic Synthesis
4-Amino-3-nitrophenol is used as a building block in the synthesis of various organic compounds, including amino acids, peptides, and heterocycles. It is also used as a reagent in organic synthesis, such as in the synthesis of 3,4-dihydroxybenzaldehyde.
Production of 4-Amino-3-nitrophenol
4-Amino-3-nitrophenol can be synthesized by various methods, including the reduction of 4-nitro-3-aminophenol, the nitration of 4-amino-3-methoxyphenol, and the diazotization of 3-nitro-4-aminophenol.
One of the commonly used methods for the synthesis of 4-Amino-3-nitrophenol is the reduction of 4-nitro-3-aminophenol using a reducing agent such as sodium dithionite or sodium borohydride. The reaction is carried out in an alkaline medium, and the product is isolated by filtration and recrystallization.
Another method for the synthesis of 4-Amino-3-nitrophenol is the diazotization of 3-nitro-4-aminophenol, which is followed by coupling with various coupling agents to produce different azo dyes.
Conclusion
4-Amino-3-nitrophenol is a versatile compound that finds application in various industries, including the dye and pigment, pharmaceutical, and organic synthesis industries. The compound is widely used as an intermediate in the synthesis of various dyes, pigments, and pharmaceuticals. The production of 4-Amino-3-nitrophenol can be carried out by various methods, including the reduction of 4-nitro-3-aminophenol and the diazotization of 3-nitro-4-aminophenol. Ningbo Inno Pharmchem Co., Ltd. is one of the leading manufacturers and suppliers of 4-Amino-3-nitrophenol from China, offering high-quality products at competitive prices.
