5-Ethyluracil: Properties, Applications, and Production
5-Ethyluracil (CAS:4212-49-1) is a pyrimidine derivative with the molecular formula C6H8N2O2. It is a white crystalline solid that is soluble in water, ethanol, and other organic solvents. The compound has several synonyms, including 5-Aethyl-1H-pyrimidin-2,4-dion, 5-Ethyl-1H-pyrimidine-2,4-dione, 2,4-Dihydroxy-5-ethylpyrimidine, Homothymine, 5-ethyl uracil, 2,4-Dihydroxy-5-ethylpyrimidine, 5-ethyl-2,4-dioxopyrimidine, DIHYDROXY-5-ETHYLPYRIMIDINE, and 5-ethvluracil.
Properties of 5-Ethyluracil:
5-Ethyluracil is a stable compound that can withstand high temperatures and pressures. It has a melting point of 266-270°C and a boiling point of 450.1°C at 760 mmHg. The compound has a density of 1.35 g/cm3 and a refractive index of 1.502. It is non-toxic and non-reactive under normal conditions.
Applications of 5-Ethyluracil:
5-Ethyluracil has several applications in the pharmaceutical and chemical industries. It is used as an intermediate in the synthesis of various drugs, such as antiviral, antitumor, and antibacterial agents. The compound is also used in the preparation of pyrimidine nucleosides, which are essential components of DNA and RNA. Additionally, 5-Ethyluracil has been reported to have anti-inflammatory and immunomodulatory properties, making it a potential therapeutic agent for treating autoimmune diseases.
Production of 5-Ethyluracil:
5-Ethyluracil can be synthesized through various methods, including the reaction of ethyl malonyl chloride with urea or ethyl carbamoyl chloride with malonic acid. Another method involves the reaction of ethyl acetoacetate with urea in the presence of a strong base. The compound can also be obtained by the reduction of 5-ethyl-2,4-dioxopyrimidine using a reducing agent such as sodium borohydride.
Conclusion:
In summary, 5-Ethyluracil is a pyrimidine derivative with several applications in the pharmaceutical and chemical industries. The compound has properties that make it stable and non-toxic, and it can be synthesized through various methods. As research continues, the potential therapeutic applications of 5-Ethyluracil may become even more apparent, making it an exciting area of study for scientists and researchers.
