3-Cyano-2-fluorobenzoic acid: Properties, Synthesis, and Applications
Introductionn3-Cyano-2-fluorobenzoic acid (CAS:219519-77-4) is a versatile organic compound that has gained significant attention in the pharmaceutical and agrochemical industries due to its unique properties. It is an aromatic carboxylic acid containing a cyano and a fluorine group attached to the benzene ring. The compound is also referred to as 3-Cyano-2-fluorobenzoic acid, Benzoic acid,3-cyano-2-fluoro, and 2-FLUORO-3-CYANOBENZOIC ACID. In this article, we will discuss the properties, synthesis, and applications of this compound.
Propertiesn3-Cyano-2-fluorobenzoic acid is a white crystalline powder with a melting point of 203-205 °C. It is sparingly soluble in water but soluble in organic solvents such as ethanol, acetone, and chloroform. The compound is stable under normal conditions and has a shelf life of several years. Its molecular formula is C8H4FNO2, and its molecular weight is 167.12 g/mol.
Synthesisn3-Cyano-2-fluorobenzoic acid can be synthesized by various methods, including the reaction of 2-fluorobenzoic acid with potassium cyanide in the presence of a catalyst, such as copper(II) chloride. The reaction takes place in a mixture of water and ethanol, and the yield of the product can be improved by controlling the reaction conditions such as temperature and reaction time. Another method involves the reaction of 2-fluorobenzonitrile with carbon dioxide in the presence of a palladium catalyst to form 3-cyano-2-fluorobenzoic acid.
Applicationsn3-Cyano-2-fluorobenzoic acid has diverse applications in various industries, including pharmaceutical, agrochemical, and fine chemical industries. The compound is a versatile intermediate used in the synthesis of several drugs, such as anti-inflammatory and anti-cancer agents. It is also used as a key building block in the synthesis of other organic compounds, such as dyes and pigments.
In the pharmaceutical industry, 3-Cyano-2-fluorobenzoic acid is used as a starting material in the synthesis of several drugs. For example, it is used in the synthesis of a potent anti-inflammatory agent, 3-(4-Fluorophenyl)-2-(methylsulfonyl)-3H-benzo[e][1,2]oxaborole. The compound is also used in the synthesis of a novel class of anti-cancer agents, such as 3-cyano-2-fluorobenzamide derivatives.
In the agrochemical industry, 3-Cyano-2-fluorobenzoic acid is used as an intermediate in the synthesis of several herbicides and fungicides. For example, it is used in the synthesis of a potent fungicide, Boscalid, which is used to control several plant diseases such as powdery mildew and downy mildew.
Conclusionn3-Cyano-2-fluorobenzoic acid is a versatile organic compound with unique properties that make it useful in various industries. Its applications in the pharmaceutical and agrochemical industries have been well-established, and it continues to be an essential building block in the synthesis of several drugs and other organic compounds. Ningbo Inno Pharmchem Co., Ltd. is a reliable manufacturer and supplier of this compound from China, and they can provide high-quality products to meet the needs of different industries.
