5-Bromo-1,3-dichloro-2-fluorobenzene: An Overview of Its Properties and Applications
5-Bromo-1,3-dichloro-2-fluorobenzene: An Overview of Its Properties and Applications
5-Bromo-1,3-dichloro-2-fluorobenzene, also known as CAS:17318-08-0, is a chemical compound with the molecular formula C6H2BrCl2F. It is a white to off-white crystalline powder that is soluble in organic solvents such as ethanol, methanol, and acetone. This article provides an overview of the properties and applications of 5-Bromo-1,3-dichloro-2-fluorobenzene.
Properties of 5-Bromo-1,3-dichloro-2-fluorobenzene
5-Bromo-1,3-dichloro-2-fluorobenzene belongs to the family of organic compounds known as halobenzenes, which are compounds that contain a benzene ring with one or more halogen atoms (fluorine, chlorine, bromine, or iodine) attached to it. Its molecular weight is 265.45 g/mol.
The melting point of 5-Bromo-1,3-dichloro-2-fluorobenzene is 48-50 °C, and its boiling point is 285-287 °C. It has a density of 1.913 g/cm3 at 25 °C and a refractive index of 1.582 at 20 °C. The compound is stable under normal conditions, but it may decompose when exposed to heat, light, or air.
Applications of 5-Bromo-1,3-dichloro-2-fluorobenzene
5-Bromo-1,3-dichloro-2-fluorobenzene has several applications in different industries. One of its primary uses is as an intermediate or building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds.
Pharmaceuticals
5-Bromo-1,3-dichloro-2-fluorobenzene is used as a starting material in the synthesis of several drugs, such as the antipsychotic drug clozapine and the anticancer drug gefitinib. These drugs have been proven to be effective in treating various diseases, including schizophrenia, non-small cell lung cancer, and breast cancer.
Agrochemicals
5-Bromo-1,3-dichloro-2-fluorobenzene is also used in the synthesis of agrochemicals such as herbicides, fungicides, and insecticides. For example, it is a key intermediate in the synthesis of the herbicide bromoxynil, which is used to control broadleaf weeds in crops such as cotton, corn, and wheat.
Other applications
Apart from its use in pharmaceuticals and agrochemicals, 5-Bromo-1,3-dichloro-2-fluorobenzene is also used as a reagent in organic synthesis. It can be used to introduce a bromine, chlorine, or fluorine atom into a molecule, which can modify its properties and improve its performance.
Safety and Handling
When handling 5-Bromo-1,3-dichloro-2-fluorobenzene, it is essential to take the necessary precautions to ensure the safety of the user and the environment. The compound is harmful if ingested, inhaled, or absorbed through the skin. It may cause irritation to the eyes, skin, and respiratory tract.
Therefore, it is essential to wear personal protective equipment such as gloves, goggles, and protective clothing when handling the compound. It is also essential to handle it in a well-ventilated area or under a fume hood to avoid inhaling the vapors.
Conclusion
5-Bromo-1,3-dichloro-2-fluorobenzene is a useful chemical compound with several applications in the pharmaceutical, agrochemical, and other industries. Its properties and applications make it an important building block in organic synthesis. However, it is essential to handle it with care and take the necessary precautions to ensure the safety of the user and the environment.
