4-Bromo-2-Fluorobenzonitrile: Properties, Applications and Synthesis
Introduction:
4-Bromo-2-fluorobenzonitrile, also known as 2-fluoro-4-bromobenzonitrile, is a colorless crystalline compound with a molecular formula of C7H3BrFN. This chemical is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is a versatile compound with a range of potential applications, and its unique properties make it an important component in various industrial processes. This article will provide an overview of the properties, applications, and synthesis of 4-Bromo-2-Fluorobenzonitrile.
Properties:
4-Bromo-2-fluorobenzonitrile is a white or off-white crystalline solid with a melting point of 63-67 °C. It is soluble in organic solvents such as methanol, ethanol, and dichloromethane but insoluble in water. The compound has a density of 1.67 g/cm3 and a boiling point of 231 °C. It is stable under normal conditions but may decompose when exposed to heat or light.
Applications:
4-Bromo-2-fluorobenzonitrile is an important intermediate in the synthesis of various chemicals. It is commonly used in the pharmaceutical industry to produce drugs such as anticancer agents, antifungal agents, and antiviral agents. The compound is also used in the agrochemical industry to produce pesticides and herbicides. Besides, it can be used in other industries like dyes, pigments, and rubber chemicals.
The compound's unique properties, such as its high reactivity and stability, make it useful in a wide range of industrial processes. For instance, it can be used in the synthesis of other organic compounds, such as heterocyclic compounds and aryl halides. It can also be used as a catalyst in various chemical reactions.
Synthesis:
4-Bromo-2-fluorobenzonitrile can be synthesized through a variety of methods. One common method involves the reaction of 2-fluorobenzonitrile with bromine in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction proceeds through the electrophilic substitution of bromine on the benzene ring, followed by the substitution of the fluorine atom with a bromine atom. The resulting product is 4-Bromo-2-fluorobenzonitrile.
Another method involves the reaction of 4-bromo-2-fluorobenzoic acid with thionyl chloride, followed by the reaction with sodium cyanide. The reaction proceeds through the formation of the acid chloride, which then reacts with sodium cyanide to form the nitrile.
Conclusion:
4-Bromo-2-fluorobenzonitrile is an important intermediate in the synthesis of various chemicals. It is widely used in the pharmaceutical and agrochemical industries, where its unique properties make it a valuable component in various industrial processes. The compound's high reactivity, stability, and versatility make it an attractive option for the synthesis of other organic compounds. Ningbo Inno Pharmchem Co., Ltd. is a reliable supplier for this product. With their expertise in chemical synthesis, they can offer custom synthesis and bulk quantities of 4-bromo-2-fluorobenzonitrile to meet the needs of various industrial applications.
