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Tianeptine_66981-73-5

Tianeptine

  • CAS:

    66981-73-5

  • Synonym:

    Tianeptine
    Tianeptina
    Tianeptinum
    Tianeotine
    7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid

Details

CAS No: 66981-73-5
Product Name: Tianeptine
Other Name:
Tianeptine
Tianeptina
Tianeptinum
Tianeotine
7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid
 
Density: 1.4±0.1 g/cm3
Boiling Point: 609.2±65.0 °C at 760 mmHg
Melting Point: 129-131°C
Molecular Formula: C21H25ClN2O4S
Molecular Weight: 436.952
Flash Point: 322.2±34.3 °C
Exact Mass: 436.122345
PSA: 95.09000
LogP: 2.57
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Index of Refraction: 1.639
 
Specification
Appearance: White powder
Assay: ≥99.0%
Residue on ignation: ≤0.20%
Loss on drying: ≤1.0%
Heavy metal: ≤20ppm
Individual impurity: ≤0.1%
Total impurities: ≤0.5%
 
Application
Mainly acting on the 5-HT system, no excitement, sedation, anti-acetylcholine and cardiac toxicity. For depression.
Tianeptine (brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra) is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
Tianeptine is a low-affinity full agonist at the μ-opioid[note 1] and δ-opioid receptors with negligible effect at the κ-opioid receptors. μ-Opioid agonists typically induce euphoria, and in accordance, tianeptine does so at high doses well above the normal therapeutic range.
Tianeptine was discovered and patented by The French Society of Medical Research in the 1960s. Currently, tianeptine is approved in France and manufactured and marketed by Laboratories Servier SA; it is also marketed in a number of other European countries under the trade name “Coaxil” as well as in Asia (including Singapore) and Latin America as “Stablon” and “Tatinol” but it is not available in Australia, Canada, New Zealand, the U.K. or the U.S..
 
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

We provide our customers with friendly, professional service and reliable, high performance products that have been manufactured according to an accredited quality management system ISO 9001:2015.We offer a wide range of custom synthesis and production services for pharmaceutical intermediates, reference compounds and new reagents for pharmaceutical companies, pharmaceutical biotech companies, universities and research institutions.Our company has won the trust of customers at home and abroad with competitive price, high quality products, quick response, high quality sales service, steady and honest style, and the concept of providing one-stop service for customers. and support.Repackaging capabilities to fit customer specific requirements.Our company is able to achieve rapid response in the product development, pilot-amplification process, and quickly transform technology into production.

Are you looking for China or India manufacturers of Tianeptine CAS:66981-73-5, Tianeptinum factory or 7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid supplier? Where can buy Tianeotine or if you want to know the price market of Tianeptine? Welcome to contact us for Tianeptine COA or MSDS.

Laboratory in Ningbo
Our company's R&D company, Ningbo Gino Chemical Co., Ltd. was established in December 2011. we have several fume hoods and kilogram laboratory, and have purchased 20L, 50L reactors and as a preliminary pilot manufacturing of the products. At the same time, We mobilized external resources to establish a pilot facility in Henan Zhumadian and Anhui Anqing, and cooperating with Shandong Zibo and Jiangsu Changzhou factories as a large production facility for our products.

Factory in Shanxi Province
At the end of 2017, We invested workshop in Xinjiang County Longzhou Chemical Co., Ltd., Xinjiang County Coal Mine Park, Yuncheng, Shanxi. The first phase of the reactors were 30* 2000L~5000L, The contract output value is 50 million annually, factory has passed the audit from public listed company domestic and abroad.

Factory in Shandong Province
The production base of liquid rectification chemical products located in Liaocheng, Shandong Province is the main outsourcing production base of our company. The products are sold to leading enterprises and listed companies in the carcass industry for many years. The production, quality and service are stable, delivery is timely, and some individual products are covering 90% of the market.

Factory in Henan Province
In year 2020, We invested workshop in Henan province, the workshop consists of 50*2000L~5000L reactors, The types of reactions that can be manufacturer there are: bromination, cyanidation, and conventional reactions.

Disclaimer: Certain products are for research use only. Not for diagnostic or therapeutic use. Not for human use. INNOPHARMCHEM does not sell to individuals. INNOPHARMCHEM does not warrant that the use or sale of the products delivered under will not infringe the claims of any China or other patents covering the product itself or the use thereof in combination with other products or the operation of any process.

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