Understanding the fundamental chemical properties and synthesis of Phentolamine Mesylate (CAS 65-28-1) is essential for its effective use in pharmaceuticals and research. This compound, known for its alpha-adrenergic antagonist activity, possesses specific characteristics that dictate its handling, formulation, and application. NINGBO INNO PHARMCHEM CO.,LTD. provides a detailed overview of these chemical aspects, supporting scientific and industrial users.

Phentolamine Mesylate is chemically identified as 3-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate. Its molecular formula is C18H23N3O4S, with a molecular weight of 377.46. Physically, it presents as a white to off-white crystalline powder. Key chemical properties include its melting point, typically reported in the range of 180-182 °C, and its solubility. It is soluble in water, with a reported solubility of 50 mg/mL, and also soluble in ethanol, at a concentration of 26 mg/mL. These solubility characteristics are important for its preparation in various dosage forms and experimental solutions.

The synthesis of Phentolamine Mesylate generally involves the reaction of phentolamine with methanesulfonic acid. The precursor, phentolamine, can be synthesized through several routes, often involving substituted anilines and imidazoline derivatives. Common raw materials used in its production may include methanesulfonic acid and intermediates derived from chloroacetonitrile or other related compounds, depending on the specific synthetic pathway employed. NINGBO INNO PHARMCHEM CO.,LTD. ensures the quality of these raw materials to guarantee the purity of the final Phentolamine Mesylate product.

The compound's stability is also a critical factor; aqueous solutions of Phentolamine Mesylate are noted as not being suitable for long-term storage, suggesting the need for careful handling and preparation protocols. Its classification as an active pharmaceutical ingredient (API) or a pharmaceutical intermediate signifies its critical role in the drug manufacturing supply chain.

For researchers and manufacturers looking to buy Phentolamine Mesylate, understanding these chemical properties is fundamental. It aids in designing appropriate experimental protocols, formulation strategies, and quality control measures. The consistent availability of high-purity Phentolamine Mesylate, supplied by NINGBO INNO PHARMCHEM CO.,LTD., is key to achieving reliable outcomes in both research and production environments.

In summary, Phentolamine Mesylate is a compound with well-defined chemical properties that facilitate its therapeutic and research applications. Its synthesis from readily available raw materials, combined with its specific solubility and stability characteristics, makes it a cornerstone chemical in the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this essential compound with the highest standards of quality.