NINGBO INNO PHARMCHEM CO.,LTD. provides a comprehensive look at the pharmacological profile of Ciprofloxacin Hydrochloride, an essential API for pharmaceutical development. Understanding these characteristics is key to formulating effective and safe medications.

The pharmacokinetic properties of Ciprofloxacin Hydrochloride are well-documented. After oral administration, it exhibits a bioavailability of approximately 60-80%, with peak plasma concentrations typically achieved within 1-2 hours. Its distribution is wide, penetrating various tissues and fluids, including the prostate and lungs, which are often difficult for antibiotics to reach. The drug is partially metabolized, primarily in the liver, into less active metabolites. Elimination occurs through both renal and non-renal routes, with an elimination half-life generally ranging from 3 to 7 hours in adults with normal renal function.

Pharmacodynamically, Ciprofloxacin Hydrochloride exerts its antibacterial effect by inhibiting bacterial DNA gyrase and topoisomerase IV. This targeted action disrupts bacterial DNA replication, leading to cell death. The drug's efficacy is often measured by its Minimum Inhibitory Concentration (MIC) against specific pathogens. Importantly, there is typically no cross-resistance with other antibiotic classes, making it valuable in treating infections resistant to other agents.

It is also crucial for pharmaceutical professionals to be aware of potential drug interactions. Ciprofloxacin Hydrochloride can interact with several drug classes, including antacids containing aluminum or magnesium, iron supplements, sucralfate, and certain dairy products, which can reduce its absorption. It may also enhance the effects of warfarin and increase serum concentrations of theophylline and caffeine. Furthermore, it carries a boxed warning regarding the increased risk of tendinitis and tendon rupture, particularly in older adults or those on corticosteroid therapy.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that our Ciprofloxacin Hydrochloride API is manufactured to the highest standards, facilitating the development of reliable pharmaceutical products. We provide detailed product specifications to support our clients in understanding these critical pharmacological aspects. By partnering with us for your ciprofloxacin hydrochloride API bulk needs, you gain access to a high-quality ingredient backed by extensive product knowledge.