Conessine, identified by CAS number 546-06-5, is a fascinating steroid alkaloid that has garnered significant attention in the scientific community due to its potent pharmacological activities.

As a key compound sourced from plants within the Apocynaceae family, Conessine demonstrates remarkable efficacy as a histamine antagonist. Its selectivity for the H3 subtype is particularly noteworthy, offering researchers a precise tool to investigate the complex roles of histamine in the central nervous system (CNS). The affinity of Conessine for the H3 receptor, measured at approximately 5 nM, positions it as a valuable probe for understanding histamineergic neurotransmission.

Furthermore, Conessine exhibits excellent pharmacokinetic properties, including substantial blood-brain barrier penetration and long CNS clearance times. This characteristic is crucial for drugs targeting neurological conditions, as it ensures adequate drug concentration at the site of action. The compound also displays a high affinity for adrenergic receptors, suggesting potential applications in areas related to cardiovascular function and sympathetic nervous system regulation. These combined properties make Conessine an attractive molecule for further study in drug discovery and development. For those seeking to purchase Conessine, reliable suppliers in China offer this compound for your research needs.

The exploration of plant-derived alkaloid pharmacology continues to yield compounds with significant therapeutic potential. Understanding the precise mechanisms of action, such as the role of histamine antagonist H3 subtype, is vital. Researchers looking to buy Conessine can benefit from its well-documented properties and its availability from reputable manufacturers. The pursuit of new treatments often begins with investigating such unique natural products.