Oxidative stress, an imbalance between free radicals and antioxidants, is a fundamental factor in cellular damage, aging, and the development of numerous diseases. Mitochondria, while essential for energy production, are also a primary source of reactive oxygen species (ROS) that contribute to oxidative stress. Humanin, a peptide originating from mitochondria, offers a novel approach to combating this cellular threat.

Humanin's mechanism of action against oxidative stress is multi-faceted. It works by protecting not only the cells but also the mitochondria themselves from ROS-induced damage. This is achieved through various signaling pathways that enhance the body's antioxidant defense systems. For instance, Humanin can activate the Keap1/Nrf2 pathway, which upregulates the expression of critical antioxidant enzymes.

Furthermore, Humanin promotes cellular repair and resilience by influencing cellular processes like autophagy, which clears damaged components, and by inhibiting inflammatory pathways. It has also been shown to directly protect mitochondria by modulating their electron transport chain activity, thereby reducing excessive ROS production. This comprehensive approach to cellular defense makes Humanin a powerful tool in the fight against oxidative stress.

NINGBO INNO PHARMCHEM CO.,LTD. recognizes the critical importance of managing oxidative stress for overall health. Our research efforts are focused on understanding and potentially harnessing the capabilities of compounds like Humanin to provide effective cellular protection strategies against the damaging effects of oxidative stress and aging.