Procaine hydrochloride, identified by its CAS number 51-05-8, is a chemical compound with a well-defined profile that underpins its extensive use as a local anesthetic and pharmaceutical intermediate. Understanding its chemical properties, including solubility, stability, and synthesis methods, is essential for anyone looking to procure or utilize this vital API powder. As a leading supplier of Procaine HCl in China, we offer insights into its detailed chemical characteristics.

Chemically, Procaine hydrochloride is a white crystalline powder or colorless transparent crystal. Its molecular formula is C13H21ClN2O2, with a molecular weight of approximately 272.77 g/mol. A key characteristic is its high solubility in water, making it ideal for injectable formulations. It is also soluble in ethanol but less so in ether. The compound’s melting point typically ranges from 155-158 °C, serving as an important indicator of its purity and quality. When considering purchasing Procaine HCl powder, verifying these physical properties is a standard practice.

Procaine hydrochloride's stability is a critical aspect for its application. While it is generally stable at room temperature, it can be sensitive to air and light, potentially leading to discoloration and degradation over time. Its aqueous solutions are most stable within a pH range of 3.0-5.0, necessitating careful formulation to maintain efficacy. This sensitivity highlights the importance of proper storage conditions and handling procedures for Procaine HCl powder to preserve its integrity. Many researchers seek to buy Procaine HCl from suppliers who guarantee appropriate packaging and storage.

The synthesis of Procaine hydrochloride primarily involves the esterification of para-aminobenzoic acid with diethylaminoethanol. Early methods, pioneered by scientists like Ernest Fourneau, laid the groundwork for modern production techniques. These processes focus on achieving high yields and exceptional purity, often involving hydrogenation and subsequent salt formation with hydrochloric acid. The synthesis pathway is crucial for pharmaceutical manufacturers aiming to produce Procaine HCl API powder that meets international pharmacopoeial standards. Understanding these synthesis routes is key for those investigating 'how to make Procaine HCl'.

The mechanism of action of Procaine hydrochloride as a local anesthetic is well-understood. It acts by blocking voltage-gated sodium channels on nerve cell membranes, thereby preventing the transmission of pain signals. This blockade effect is reversible and dose-dependent. Its application in various medical and dental procedures relies on this specific pharmacological action. As a supplier, we ensure our Procaine HCl powder is manufactured with precision to deliver this intended effect reliably.

In conclusion, the chemical profile of Procaine hydrochloride—from its physical characteristics to its synthesis and stability—underscores its importance in the pharmaceutical industry. These properties dictate its application as a reliable local anesthetic and a valuable research chemical. If you are in the market to purchase Procaine HCl powder, partnering with a knowledgeable and quality-focused supplier like us ensures you receive a product that meets all your demanding requirements.