In the complex landscape of pharmaceutical formulation and patient care, a thorough understanding of drug interactions is paramount, especially for potent APIs like Rivaroxaban. As a leading manufacturer and supplier of Rivaroxaban (CAS 27620-10-6), we recognize the importance of providing comprehensive information that extends beyond basic product specifications. This guide focuses on the critical drug interactions associated with Rivaroxaban, aiming to assist pharmaceutical professionals in making informed decisions.

Rivaroxaban, an anticoagulant, works by inhibiting factor Xa to prevent blood clot formation. However, its efficacy and safety can be significantly influenced by concurrent use with other medications. A key concern is the co-administration with other antiplatelet agents or anticoagulants, such as aspirin, warfarin, clopidogrel, or NSAIDs (like ibuprofen and naproxen). These combinations can substantially increase the risk of bleeding, a serious side effect of Rivaroxaban. Procurement managers and R&D scientists should be aware that even common over-the-counter medications can pose risks.

Furthermore, certain medications can alter the plasma levels of Rivaroxaban, potentially affecting its therapeutic activity or increasing side effects. Drugs that inhibit or induce the cytochrome P450 enzyme system, particularly CYP3A4, play a significant role. For instance, strong CYP3A4 inhibitors like ketoconazole or certain antibiotics (e.g., clarithromycin) can increase Rivaroxaban levels, leading to a heightened risk of bleeding. Conversely, strong CYP3A4 inducers like rifampin can decrease Rivaroxaban levels, potentially reducing its effectiveness. Identifying these interaction patterns is crucial for formulators and clinicians.

Herbal supplements, such as St. John's wort, also warrant attention as they can interact with Rivaroxaban. Even seemingly benign substances like grapefruit juice can affect Rivaroxaban's metabolism, emphasizing the need for a holistic approach to patient management. For pharmaceutical professionals, understanding these interactions helps in developing patient counseling materials and ensuring the safety profile of drugs containing Rivaroxaban.

As a dedicated supplier of Rivaroxaban, we are committed to providing our clients with not only high-purity API but also critical safety and handling information. We encourage our partners to consult with healthcare providers regarding potential drug interactions. By fostering informed collaboration, we contribute to the safe and effective use of Rivaroxaban in pharmaceutical products. When you buy Rivaroxaban from us, you gain a partner invested in the success and safety of your formulations.