In the intricate world of pharmaceuticals, understanding the fundamental science behind each ingredient is crucial for innovation and quality assurance. Glycochenodeoxycholic Acid Sodium Salt (CAS: 16564-43-5), a well-defined Active Pharmaceutical Ingredient (API) and biochemical compound, offers a fascinating case study in the importance of chemical properties and biological functions.

Chemical Structure and Properties
Glycochenodeoxycholic Acid Sodium Salt is the sodium salt of glycochenodeoxycholic acid, which is a conjugated form of chenodeoxycholic acid. As a bile acid, it possesses a characteristic steroidal structure with hydroxyl groups and a conjugated glycine moiety. This structure dictates its amphipathic nature, allowing it to interact with both aqueous and lipid environments. Key properties relevant to pharmaceutical buyers include its molecular weight, solubility, and stability. Typically supplied as a white to off-white powder with a purity exceeding 99%, its consistent physical and chemical characteristics are vital for reliable application in drug formulations and research.

Biological Significance and Mechanisms
In biological systems, bile acids like Glycochenodeoxycholic Acid Sodium Salt are synthesized in the liver and play critical roles in digestion, absorption of fats and fat-soluble vitamins, and cholesterol homeostasis. They act as signaling molecules, interacting with specific nuclear receptors (like the Farnesoid X Receptor, FXR) and G protein-coupled receptors, thereby regulating gene expression related to metabolism. Understanding these mechanisms is essential for researchers investigating metabolic diseases, liver disorders, and inflammatory conditions. When purchasing this API, scientists rely on its proven biological activity for their experimental designs.

Applications in Pharmaceutical Development
The pharmaceutical industry leverages the unique properties of Glycochenodeoxycholic Acid Sodium Salt in several ways:

  • Therapeutic Potential: Research is ongoing into the therapeutic applications of bile acids and their derivatives, particularly in treating liver diseases, metabolic syndrome, and certain gastrointestinal disorders.
  • Biochemical Reagent: Its well-defined properties make it an invaluable tool in biochemical research for studying enzyme kinetics, receptor binding assays, and cellular signaling pathways. Researchers often buy this compound for its purity and consistency.
  • Drug Delivery Systems: The amphipathic nature of bile acids is being explored for use in drug delivery systems, such as liposomes or micelles, to improve the solubility and bioavailability of poorly soluble drugs.

Procurement Considerations for Quality
For any application, particularly in the pharmaceutical sector, obtaining Glycochenodeoxycholic Acid Sodium Salt from a reputable manufacturer is crucial. Suppliers adhering to GMP standards ensure that the chemical is produced under controlled conditions, guaranteeing high purity and freedom from contaminants. Buyers should always verify the CAS number (16564-43-5) and request detailed specifications, including assay results and any relevant certifications. Sourcing from experienced API manufacturers in China can provide access to high-quality material at competitive prices.

The scientific understanding of Glycochenodeoxycholic Acid Sodium Salt continues to expand, revealing its importance not only as a basic biochemical entity but also as a key player in pharmaceutical innovation. By prioritizing quality and understanding its fundamental properties, companies can effectively utilize this versatile compound.