Lidocaine Hydrochloride Powder is a cornerstone in modern pharmacology, valued for its potent local anesthetic and antiarrhythmic properties. Understanding the science behind this compound—its chemical structure, physical properties, and mechanisms of action—is crucial for researchers, formulators, and anyone seeking to comprehend its widespread medical applications.

Chemically, Lidocaine Hydrochloride is the hydrochloride salt of lidocaine, an amide-type local anesthetic. Its molecular formula is C14H22N2O · HCl, with a molecular weight of approximately 288.81 g/mol. The compound typically presents as a white, crystalline powder. This physical form is a key characteristic when sourcing, and manufacturers often highlight 'Lidocaine Hydrochloride Powder' in their product descriptions.

One of the most significant properties of Lidocaine Hydrochloride Powder is its solubility. It is highly soluble in water (around 50 mg/mL at room temperature) and also dissolves well in polar organic solvents like ethanol and methanol. This solubility profile is critical for its formulation into injectable solutions, topical creams, and other dosage forms. The hydrochloride salt form ensures good water solubility, which is essential for intravenous and infiltration anesthesia, unlike the free base, which is less water-soluble and more lipophilic.

The primary pharmacological mechanism of Lidocaine Hydrochloride Powder is its ability to block voltage-gated sodium channels (Nav channels) in neuronal membranes. By binding to these channels, lidocaine stabilizes the resting membrane potential and prevents the rapid influx of sodium ions that is necessary for the initiation and conduction of nerve impulses. This blockade effectively prevents pain signals from reaching the central nervous system, resulting in local anesthesia. This mechanism is central to its use when purchasing for anesthetic applications.

Furthermore, lidocaine also affects cardiac sodium channels, albeit with different kinetics and concentrations. In the heart, it can reduce the rate of depolarization and slow conduction velocity, making it effective in treating certain cardiac arrhythmias, particularly ventricular arrhythmias. This dual action—nerve blockade and cardiac electrophysiological effects—underscores its therapeutic versatility. Researchers often investigate these specific mechanisms when purchasing 'pure Lidocaine Hydrochloride Powder' for scientific studies.

When sourcing this compound, understanding its 'CAS number' (typically 6108-05-0 for the monohydrate) and purity is paramount. A reliable 'manufacturer' or 'supplier' will ensure that the material supplied meets stringent quality standards, such as USP or BP. This meticulous attention to detail by the 'supplier' ensures that the scientific integrity of research and the safety of patients are maintained. For those looking to 'buy' Lidocaine Hydrochloride Powder, understanding these scientific underpinnings ensures you are acquiring a product fit for its intended purpose.