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Dutasteride (CAS 164656-23-9) operates by inhibiting the 5-alpha reductase enzymes. There are two primary isoforms of this enzyme: type 1 and type 2. Both isoforms play a role in converting testosterone into dihydrotestosterone (DHT). DHT is a potent androgen that is intricately linked to male pattern baldness. In susceptible individuals, DHT causes hair follicles on the scalp to shrink, leading to thinner hair and eventual hair loss. Dutasteride's unique ability to inhibit both type 1 and type 2 isoenzymes results in a more profound and sustained reduction of DHT levels across the body, including the scalp, compared to inhibitors that target only one isoform.

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