Teduglutide has emerged as a vital treatment option for individuals living with Short Bowel Syndrome (SBS), a condition marked by malabsorption and the frequent need for parenteral support (PS). Effective management with teduglutide hinges on understanding its prescribed dosage and proper administration techniques. As a reputable supplier, we aim to provide clarity on how to best utilize this life-changing peptide therapy.

Understanding Teduglutide Dosage for SBS

The dosage of teduglutide is typically determined based on the patient's body weight. For both adult and pediatric patients (one year of age and older) diagnosed with SBS requiring additional nutrition or fluids from PS, the recommended dosage is 0.05 mg per kilogram of body weight per day. This weight-based dosing ensures that the therapeutic benefits of teduglutide are optimized for each individual. It is crucial for patients to adhere strictly to the dosage prescribed by their healthcare provider.

Administration: The Subcutaneous Injection

Teduglutide is administered via subcutaneous injection, meaning it is injected into the fatty tissue just under the skin. The injection sites commonly recommended include the abdomen, upper thighs, or upper arms. Patients are advised to rotate injection sites to prevent irritation and maintain skin integrity. Before initiating self-administration, patients receive comprehensive training from healthcare professionals on how to prepare the medication, measure the correct dose, and perform the injection safely.

Preparation and Injection Steps for Patients

The preparation of teduglutide involves mixing a sterile powder with a diluent. The process typically includes:

  • Gathering all necessary supplies: teduglutide vial, diluent, syringes, needles, and alcohol swabs.
  • Cleaning the vial's rubber seal with an alcohol pad.
  • Mixing the teduglutide powder with the diluent according to the provided instructions.
  • Drawing the correct, prescribed dose into a separate dosing syringe.
  • Cleaning the chosen injection site with an alcohol swab.
  • Injecting the medication subcutaneously at a 45-degree angle.
  • Safely disposing of all used materials, including needles and syringes, in a sharps container.

It is essential that teduglutide is injected within 3 hours of mixing. Patients should never reuse needles or syringes and should always follow safe disposal practices. For pediatric patients, administration should be performed by a trained adult, such as a parent or healthcare provider.

Storage and Handling of Teduglutide

Proper storage is vital for maintaining the efficacy of teduglutide. The powder should be stored at room temperature, below 77°F (25°C), and must not be frozen. It should be used before the expiration date indicated on the kit. Unused, mixed teduglutide should be discarded, as it is for single use only. Keeping the medication out of reach of children is paramount.

By adhering to these dosage and administration guidelines, patients can effectively manage their Short Bowel Syndrome with teduglutide, working towards reduced reliance on parenteral support and an improved quality of life. Always consult with your healthcare provider for personalized guidance.