The Chemistry of Auranofin: Structure, Synthesis, and Applications
The field of medicinal chemistry constantly seeks compounds with novel structures and therapeutic applications. Auranofin, a gold-containing organometallic compound, stands out for its unique chemical properties and significant impact on healthcare, particularly in the treatment of rheumatoid arthritis. This article explores the chemistry of Auranofin, including its molecular structure, synthesis, and the diverse applications derived from its composition. We also touch upon the importance of sourcing quality Auranofin from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD.
Molecular Structure and Formula:
Auranofin's chemical name is Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-. Its molecular formula is C20H34AuO9P, and it has a molecular weight of approximately 678.54 g/mol. The structure features a central gold(I) atom coordinated to a triethylphosphine ligand and a thioglucose moiety where the glucose is acetylated at the hydroxyl groups. This specific arrangement of gold, phosphorus, and sulfur contributes to its stability and biological activity.
Synthesis and Manufacturing:
The synthesis of Auranofin typically involves the reaction of a gold(I) salt with acetylated thioglucose and triethylphosphine. While the precise industrial synthesis pathways are proprietary, the general approach involves carefully controlled chemical reactions to achieve the desired molecular structure and purity. The quality of raw materials and meticulous process control are essential for producing high-purity Auranofin suitable for pharmaceutical use. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., a prominent fine chemical supplier in China, employ advanced techniques to ensure the consistent production of this compound.
Applications Beyond Rheumatoid Arthritis:
While Auranofin is best known for its role as a DMARD in treating rheumatoid arthritis, its chemical structure and biological activity have spurred research into other potential applications. As mentioned previously, studies have indicated that Auranofin possesses anti-cancer properties by targeting key cellular pathways like thioredoxin reductase. Furthermore, its ability to inhibit bacterial growth suggests a role in combating infectious diseases, potentially offering solutions against antibiotic-resistant strains.
Importance of Purity and Sourcing:
The effectiveness and safety of Auranofin in its therapeutic applications are directly dependent on its purity. Impurities can alter its pharmacological profile, leading to reduced efficacy or increased toxicity. Therefore, sourcing Auranofin from reputable manufacturers with stringent quality control measures is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-purity Auranofin, meeting the rigorous demands of the pharmaceutical and research sectors. Our commitment ensures that researchers and manufacturers can purchase Auranofin with confidence.
In conclusion, the chemistry of Auranofin is fascinating, encompassing a unique gold-based structure that lends itself to significant therapeutic applications. From its primary use in rheumatoid arthritis to its emerging roles in oncology and microbiology, Auranofin continues to be a compound of great interest. NINGBO INNO PHARMCHEM CO.,LTD. is a key player in making this important chemical accessible for global research and development.
Molecular Structure and Formula:
Auranofin's chemical name is Gold, [1-(thio-kS)-b-D-glucopyranose2,3,4,6-tetraacetato](triethylphosphine)-. Its molecular formula is C20H34AuO9P, and it has a molecular weight of approximately 678.54 g/mol. The structure features a central gold(I) atom coordinated to a triethylphosphine ligand and a thioglucose moiety where the glucose is acetylated at the hydroxyl groups. This specific arrangement of gold, phosphorus, and sulfur contributes to its stability and biological activity.
Synthesis and Manufacturing:
The synthesis of Auranofin typically involves the reaction of a gold(I) salt with acetylated thioglucose and triethylphosphine. While the precise industrial synthesis pathways are proprietary, the general approach involves carefully controlled chemical reactions to achieve the desired molecular structure and purity. The quality of raw materials and meticulous process control are essential for producing high-purity Auranofin suitable for pharmaceutical use. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., a prominent fine chemical supplier in China, employ advanced techniques to ensure the consistent production of this compound.
Applications Beyond Rheumatoid Arthritis:
While Auranofin is best known for its role as a DMARD in treating rheumatoid arthritis, its chemical structure and biological activity have spurred research into other potential applications. As mentioned previously, studies have indicated that Auranofin possesses anti-cancer properties by targeting key cellular pathways like thioredoxin reductase. Furthermore, its ability to inhibit bacterial growth suggests a role in combating infectious diseases, potentially offering solutions against antibiotic-resistant strains.
Importance of Purity and Sourcing:
The effectiveness and safety of Auranofin in its therapeutic applications are directly dependent on its purity. Impurities can alter its pharmacological profile, leading to reduced efficacy or increased toxicity. Therefore, sourcing Auranofin from reputable manufacturers with stringent quality control measures is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-purity Auranofin, meeting the rigorous demands of the pharmaceutical and research sectors. Our commitment ensures that researchers and manufacturers can purchase Auranofin with confidence.
In conclusion, the chemistry of Auranofin is fascinating, encompassing a unique gold-based structure that lends itself to significant therapeutic applications. From its primary use in rheumatoid arthritis to its emerging roles in oncology and microbiology, Auranofin continues to be a compound of great interest. NINGBO INNO PHARMCHEM CO.,LTD. is a key player in making this important chemical accessible for global research and development.
Perspectives & Insights
Core Pioneer 24
“Therefore, sourcing Auranofin from reputable manufacturers with stringent quality control measures is paramount.”
Silicon Explorer X
“is dedicated to providing high-purity Auranofin, meeting the rigorous demands of the pharmaceutical and research sectors.”
Quantum Catalyst AI
“Our commitment ensures that researchers and manufacturers can purchase Auranofin with confidence.”