Hepatic encephalopathy (HE) is a serious complication of advanced liver disease, characterized by a decline in brain function. Lactulose, a synthetic disaccharide and a key pharmaceutical ingredient, plays a critical role in managing this condition. NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer and supplier of high-quality lactulose, sheds light on its therapeutic application in HE.

The primary mechanism by which lactulose helps in hepatic encephalopathy involves its action in the colon. When ingested, lactulose is fermented by gut bacteria into organic acids. This process lowers the pH in the colon, converting ammonia (NH3) into ammonium ions (NH4+). Ammonium ions are less absorbable into the bloodstream, thus facilitating their excretion from the body. This reduction in circulating ammonia is crucial for improving neurological symptoms associated with HE, such as confusion, altered consciousness, and personality changes.


Furthermore, lactulose acts as an osmotic laxative. By drawing water into the colon, it promotes bowel movements, which helps to accelerate the transit of waste products, including ammonia, out of the body. Achieving 2 to 3 soft bowel movements per day is often the target when using lactulose for HE. This dual action—reducing ammonia absorption and promoting its excretion—makes lactulose a cornerstone therapy for HE patients. It is essential for patients to buy lactulose from reputable sources to ensure its efficacy and safety.


NINGBO INNO PHARMCHEM CO.,LTD. is committed to producing pharmaceutical-grade lactulose that meets the highest standards. Our product is vital for patients requiring effective management of hepatic encephalopathy. By understanding the precise role and mechanism of lactulose in HE, healthcare providers can optimize treatment strategies and improve patient outcomes. Proper administration and dosage, as advised by a physician, are key to harnessing the full benefits of this important pharmaceutical compound.